Summary
The relation between blood glucose control and erythrocyte adhesion to cultured human vascular endothelial cells was studied in 12 Type 1 (insulin-dependent) diabetic patients. Erythrocyte adhesion was measured before, 8 days and 6 weeks after continuous subcutaneous insulin infusion (CSII). Compared to controls, erythrocyte adhesion expressed as an adhesion ratio was increased in 10 diabetic patients at the first examination (adhesion ratio > 1.52). After 8 days, adhesion ratio was normalized in 5 patients. After 6 weeks, adhesion ratio was normal in 7 patients and significantly lower in the group of 12 patients (p < 0.01). The adhesion ratio was significantly correlated with glycosylated haemoglobin values (p < 0.001). Insulin did not directly affect erythrocyte adhesion. Adequate insulin treatment modifies erythrocyte adhesion through a metabolic effect which needs longer than 1 week to be effective.
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Wautier, J.L., LeBlanc, H., Wautier, M.P. et al. Erythrocyte adhesion to cultured endothelium and glycaemic control in Type I (insulin-dependent) diabetic patients. Diabetologia 29, 151–155 (1986). https://doi.org/10.1007/BF02427085
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DOI: https://doi.org/10.1007/BF02427085