Abstract
Two methods for 3D realignment of activation brain single-photon emission tomographic (SPET) studies are analyzed. The first is based on principal axes transformation (PAT). The second uses the results of the first method as initial values to start a least-squares iterative process (LS) to search for the maximum value of the correlation function. Both methods were tested with simulated and real studies. The results of the PAT method showed a maximum translation error of 0.3±0.1 pixels and a rotational error of 1.2±0.7 degrees in a total of 100 runs. For the LS method these errors were 0.2±0.1 and 0.6±0.3. The realignment for 34 real studies was assessed by three expert observers. The alignment was found to be satisfactory in all cases for the LS method, and in 18 cases (53%) for the PAT method. From the results we conclude that a combination of both methods allows the accurate realignment of SPET neuroactivation studies.
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Alpert NM, Bradshaw JF, Kennedy D, Correia JA. The principal axes transformation — a method for image registration.J Nucl Med 1990; 31: 1717–1722.
Woods RP, Cherry SR, Mazziotta JC. Rapid automated algorithm for aligning and reslicing PET images.J Comput Assist Tomogr 1992; 16: 620–633.
Minoshima S, Berger KL, Lee KS, Mintun MA. An automated method for rotational correction and centering of three-dimensional functional brain images.J Nucl Med 1992; 33: 1579–1585.
Pelizzari CA, Chen GTI, Spelbring DR, Weichslebaum. Accurate three-dimensional registration of CT, PET and/or MR images of the brain.J Comput Assist Tomogr 1989; 13: 20–26.
Levin DN, Pelizzari CA, Chen GTI, Chen CT, Cooper MD. Retrospective geometric correlation of MR, CT and PET images.Radiology 1988; 169: 817–823.
Junck L, Moen JG, Hutchins GD, Brown MB, Kuhl DE. Correlation methods for the centering rotation, and alignment of functional brain images.J Nucl Med 1990; 31: 1220–1276.
Ros D, Juvells I, Pavia J, Garcia J. Thallium-201 myocardial planar scintigrams. Alignment of stress and rest images by correlation.Phys Med Biol 1989; 34: 875–884.
Juvells I, Ros D, Pavia J, Garcia A. Evaluation of thallium myocardial perfusion imaging by means of washout parametric images: a simulation study.J Opt Soc Am A 1991; 8: 157–163.
Pladellorens J, Juvells I, Ros D. Determination of the relative orientation between two images by correlation of unidimensional functions.J Opt 1987; 18: 203–208.
Goldstein H. Classical mechanics. Reading, Mass.: AddisonWesley, 1959
Nelder JA, Mead R. A simplex method for function minimization.Comput J 1965; 7: 308–313.
Catafau A, Parellada E, Lomeña FJ, et al. Prefrontal and temporal blood flwo in schizophrenia: resting and activation HMPAO-SPECT patterns in neuroleptic-naive, young acute patients.J Nucl Med 1994; 35: 935–941.
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Pavía, J., Rose, D., Catafau, A.M. et al. Three-dimensional realignment of activation brain single-photon emission tomographic studies. Eur J Nucl Med 21, 1298–1302 (1994). https://doi.org/10.1007/BF02426693
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DOI: https://doi.org/10.1007/BF02426693