We have analyzed the design and operation of hollow fiber bioreactors for cell culture on the basis of cell growth efficiency and non-uniform fiber spacing. Operating diagrams are presented that describe reactor performance as a function of important operating variables like oxygen concentration and the fiber packing density. The diagrams allow one to find the best set of operating conditions for a fixed reactor design, or to rationally adjust the design parameters for fixed operating conditions.
Waste Water Water Pollution Oxygen Concentration Design Parameter Packing Density
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List of Symbols
feed oxygen concentration (mass/volume)
diffusivity of oxygen in continuous cell mass (length/time)
Cima, L.G.;Blanch, H.W.;Wilke, C.R.: A theoretical and experimental evaluation of a novel radial-flow hollow fiber reactor for mammalian cell culture. Bioproc. Engr.5 (1990) 19–30CrossRefGoogle Scholar