Bioprocess Engineering

, Volume 15, Issue 6, pp 327–330 | Cite as

Design and operating criteria for hollow fiber bioreactors

  • C. Sardonini
  • D. DiBiasio


We have analyzed the design and operation of hollow fiber bioreactors for cell culture on the basis of cell growth efficiency and non-uniform fiber spacing. Operating diagrams are presented that describe reactor performance as a function of important operating variables like oxygen concentration and the fiber packing density. The diagrams allow one to find the best set of operating conditions for a fixed reactor design, or to rationally adjust the design parameters for fixed operating conditions.


Waste Water Water Pollution Oxygen Concentration Design Parameter Packing Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Symbols


feed oxygen concentration (mass/volume)


diffusivity of oxygen in continuous cell mass (length/time)


outer radius of hollow fiber (length)



packing efficiency (dimensionless)


Thiele modulus (dimensionless)


cellular oxygen consumption rate (mass/volume-time)


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • C. Sardonini
    • 1
  • D. DiBiasio
    • 2
  1. 1.Unisyn Technologies, Inc.Hopkington
  2. 2.Department of Chemical EngineeringWorcester Polytechnic InstituteWorcester

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