Archiv für Toxikologie

, Volume 30, Issue 2, pp 103–110 | Cite as

Investigation of the accumulation of fat in the kidneys of mice poisoned with carbon tetrachloride

  • C. -J. Estler
  • B. Schmidt
  • H. -J. Pesch
Article

Abstract

In mice carbon tetrachloride (3 μ.l/g i.p.) causes an increase in kidney weight, water and triglyceride content after 6h, which is even more pronounced after 12 h. The increase in the renal fat content is closely paralleled by an increase in the serum non-esterified fatty acids. Since both the elevation of the non-esterified fatty acid level in the serum and the increase in the renal triglyceride content can be prevented by the antilipolytic drug ß-pyridylcarbinol (500 μg/g i.m. every 6 h) it is assumed that the accumulation of fat in the kidneys produced by carbon tetrachloride is the result of enhanced lipolysis and uptake of fatty acids into the kidneys, with subsequent esterification of the fatty acids to triglycerides.β-pyridylcarbinol had no influence on the increase in the weight and water content of the kidneys and the morphological changes (albuminous swelling, constriction of the lumen of the tubuli, increased protein permeability) produced in the tubule system by carbon tetrachloride.

Key Words

Non-Esterified Fatty Acids Renal Triglycerides Kidney Weight Carbon Tetrachloride β-Pyridylcarbinol 

Zusammenfassung

Tetrachlorkohlenstoff (3 μl/g i.p.) führt bei Mäusen nach 6 und in noch stärkerem Maße nach 12 Std zu einer Vergrößerung der Nieren sowie einer Zunahme des renalen Wasser- und Triglyceridgehalts. Dem Anstieg des Fettgehalts der Nieren geht eine Vermehrung der unveresterten Fettsäuren im Serum parallel. Sowohl der Anstieg der unveresterten Fettsäuren im Serum als auch die Zunahme der Triglyceride in der Niere lassen sich durchβ-Pyridylcarbinol (500 μg/g i.m. alle 6 Std) verhindern. Daraus wird geschlossen, daß die durch Tetrachlorkohlenstoff verursachte Zunahme des Nierenfetts das Resultat einer gesteigerten Lipolyse sowie einer vermehrten Aufnahme von Fettsäuren in die Niere mit nachfolgender Veresterung der Fettsäuren zu Triglyceriden darstellt. Auf die unter Tetrachlorkohlenstoff zu beobachtende Vergrößerung der Nieren, die Zunahme des renalen Wassergehalts und die damit im Zusammenhang stehenden morphologischen Veränderungen im Bereich des Tubulus contortus (Trübe Schwellung, Einengung des Tubuluslumens, vermehrtes Auftreten von Eiweiß in den Tubuli) hatteβ-Pyridylcarbinol keinen Einfluß.

Schlüsselwörter

Nicht veresterte Fettsäuren Triglyceride in der Niere Nierengewichte Tetrachlorkohlenstoff β-Pyridylcarbinol 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • C. -J. Estler
    • 1
  • B. Schmidt
    • 1
  • H. -J. Pesch
    • 2
  1. 1.Pharmakologisches Institut der Universität Erlangen-NürnbergErlangenGermany
  2. 2.Pathologisch-anatomisches Institut der Universität Erlangen-NürnbergErlangenGermany

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