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An epitope on C4 β light (L) chains detected by human anti-Rg; its relationship with β chain polymorphism and MHC associations

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Abstract

Two out of ten Rg-specific antisera tested contain a third antibody specific for the β chain of C4. Analysis of the β chains of 66 unrelated individuals by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the epitope detected is located exclusively on the light (L) β chain. A strong, but incomplete, association between the β chain epitope and the expression of the Rg: 2 determinant on the α chain of the same protein was also observed. While H (heavy) and L β chains were not associated with a particular C4 isotype, previously unrecorded associations of β chain polymorphism with theDR locus have been established.

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  1. Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, W12 ONN, London, UK

    Tracy Robson, Robert N. S. Heard & Carolyn M. Giles

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  1. Tracy Robson
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  2. Robert N. S. Heard
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  3. Carolyn M. Giles
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Robson, T., Heard, R.N.S. & Giles, C.M. An epitope on C4 β light (L) chains detected by human anti-Rg; its relationship with β chain polymorphism and MHC associations. Immunogenetics 30, 344–349 (1989). https://doi.org/10.1007/BF02425274

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  • DOI: https://doi.org/10.1007/BF02425274

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