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Immunogenetics

, Volume 30, Issue 2, pp 81–88 | Cite as

Genetic control of rat heart allograft rejection: effect of different MHC and non-MHC incompatibilities

  • J. Klempnauer
  • B. Steiniger
  • R. Lück
  • E. Günther
Article

Abstract

We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolated incompatibility at class I antigens encoded by theRT1. A andRT1. C regions failed to induce rejection within the observation period of 100 days, whereas class II antigens encoded by theRT1.B/D region provoked rapid rejection within 10 days. By comparison of the rejection times of isolated and combined incompatibilities a number of functional interactions could be demonstrated between individual MHC regions which either prolonged or shortened allograft survival. In contrast to rapid rejection of MHC-mismatched heart allografts, differences at non-MHC histocompatibility antigens were associated with graft survival beyond 100 days, although chronic rejection of variable severity was detected histologically. Disparity at non-MHC plus class I antigens, however, provoked acute heart allograft rejection.

Keywords

Major Histocompatibility Complex Gene Product Genetic Control Graft Survival Functional Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. Klempnauer
    • 1
  • B. Steiniger
    • 2
  • R. Lück
    • 1
  • E. Günther
    • 3
  1. 1.Klinik für Abdominal- und TransplantationschirurgieMedizinische HochschuleHannover 61Federal Republic of Germany
  2. 2.Abteilung V, Zentrum AnatomieMedizinische HochschuleHannover 61Federal Republic of Germany
  3. 3.Abteilung ImmungenetikZentrum Hygiene und Humangenetik der UniversitätGöttingenFederal Republic of Germany

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