, Volume 30, Issue 2, pp 81–88 | Cite as

Genetic control of rat heart allograft rejection: effect of different MHC and non-MHC incompatibilities

  • J. Klempnauer
  • B. Steiniger
  • R. Lück
  • E. Günther


We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolated incompatibility at class I antigens encoded by theRT1. A andRT1. C regions failed to induce rejection within the observation period of 100 days, whereas class II antigens encoded by theRT1.B/D region provoked rapid rejection within 10 days. By comparison of the rejection times of isolated and combined incompatibilities a number of functional interactions could be demonstrated between individual MHC regions which either prolonged or shortened allograft survival. In contrast to rapid rejection of MHC-mismatched heart allografts, differences at non-MHC histocompatibility antigens were associated with graft survival beyond 100 days, although chronic rejection of variable severity was detected histologically. Disparity at non-MHC plus class I antigens, however, provoked acute heart allograft rejection.


Major Histocompatibility Complex Gene Product Genetic Control Graft Survival Functional Interaction 
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. Klempnauer
    • 1
  • B. Steiniger
    • 2
  • R. Lück
    • 1
  • E. Günther
    • 3
  1. 1.Klinik für Abdominal- und TransplantationschirurgieMedizinische HochschuleHannover 61Federal Republic of Germany
  2. 2.Abteilung V, Zentrum AnatomieMedizinische HochschuleHannover 61Federal Republic of Germany
  3. 3.Abteilung ImmungenetikZentrum Hygiene und Humangenetik der UniversitätGöttingenFederal Republic of Germany

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