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Biosynthesis of antibiotics in streptomycetes

  • N. D. Lomovskaya
  • G. V. Sezonov
Industrial Applications
  • 150 Downloads

Keywords

Streptomyces Cellular Biology Chlortetracycline Tylosin Prodigiosin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baltz, R.H. & Seno, E.T. 1988 Genetics ofStreptomyces fradiae and tylosin biosynthesis.Annual Review of Microbiology 42, 547–574.CrossRefGoogle Scholar
  2. Beckmann, R.J., Cox, K. & Seno, E.T. 1989 A cluster of tylosin biosynthetic genes is interrupted by a structurally unstable segment containing four repeated sequences. InGenetics and Molecular Biology of Industrial Microorganisms, eds Hershberger, C.L., Queener, S.W. & Hegeman, G. pp. 176–186. Washington: American Society for Microbiology.Google Scholar
  3. Bergh, S. & Uhlen, M. 1990 A polyketide synthase gene cluster fromStreptomyces curacoi: cloning and expression. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC301.Google Scholar
  4. Binnie, C., Warren, M. & Butler, M.J. 1989 Cloning and heterologous expression inStreptomyces lividans ofStreptomyces rimosus genes involved in oxytetracycline biosynthesis.Journal of Bacteriology 171, 887–895.Google Scholar
  5. Boccard, F., Smokvina, T., Pemodet, J.-L., Friedmann, A. & Guerineau, M. 1989 Structural analysis of loci involved in pSAM2 site-specific integration inStreptomyces.Plasmid 21, 59–70.CrossRefGoogle Scholar
  6. Brown, D.P., Chiang, S.-JD., Tuan, J.S. & Katz, L 1988 Site-specific integration ofSaccharopolyspora erythrea and multisite integration inStreptomyces lividans of actinomycete plasmid pSE101.Journal of Bacteriology 170, 2287–2295.Google Scholar
  7. Butler, M.J., Friend, E.J., Hunter, I.S., Kaczmarek, F.S., Sugden, D.A. & Warren, M. 1989 Molecular cloning of resistance genes and architecture of the linked gene cluster involved in biosynthesis of oxytetracycline byStreptomyces rimosus.Molecular and General Genetics 215, 231–238.CrossRefGoogle Scholar
  8. Champness, W., Riggle, P. & Admidis, T. 1990 Loci involved in regulation of antibiotic synthesis. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC006.Google Scholar
  9. Chinenova, T.A., Biryukova, I.V., Emelyanova, L.K., Klochkova, O.A., Sezonov, G.V. & Lomovskaya, N.D. 1990 The determinants of resistance to chlortetracycline and other antibiotics inStreptomyces aureofaciens strain—the producer of chlortetracycline.Genetika (USSR) 26, 636–647.Google Scholar
  10. Cortes, J., Haydock, S.F., Roberts, G.A.et al. 1990 Analysis of the erythromycin biosynthetic gene cluster fromSaccharopolyspora erythraea. InAbstracts of 6th International Symposium on Genetics and Industrial Microorganisms, Strasbourg, 12–18 August 1990, FR, A120.Google Scholar
  11. Cox, K.L. & Seno, E.T. 1990 Maintenance of cloned tylosin biosynthetic genes inStreptomyces fradiae on freely-replicating and integrative plasmid vectors. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC016.Google Scholar
  12. Cox, K.L., Fishman, S.E., Larson, J.L.et al. 1986 The use of recombinant DNA technology to study tylosin biosynthesis and resistance inStreptomyces fradiae.Natural Products 49, 971–980.CrossRefGoogle Scholar
  13. Danilenko, V.N., Ukhabotina, L.S., Guriev, S.O. & Navashin, S.M. 1990 Cloning and structural study of erythromycin biosynthesis and resistance clustered genes fromStreptomyces erythraeus.Doklady Acad. Nauk (USSR) 310, 218–222.Google Scholar
  14. Donovan, M.J., Borell, C.W. Wendt-Pienkowski, E. & Hutchinson, C.R. 1988 Genetics of polyether antibiotic biosynthesis.Abstracts of the ASM Conference on the Genetics and Molecular Biology of Industrial Microorganisms. Bloomington, No. 10.Google Scholar
  15. Fishman, S.E., Cox, K.L., Larson, J.L.et al. 1987 Cloning genes for the biosynthesis of macrolide antibiotic.Proceedings of the National Academy of Sciences, USA 84, 8248–8252.CrossRefGoogle Scholar
  16. Hallam, S.E., Malpartida, F. & Hopwood, D.A. 1988 Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis inStreptomyces coelicolor.Gene 74, 305–320.CrossRefGoogle Scholar
  17. Hara, O., Horinouchi, T., Ouzumi, T. & Beppu, T. 1983 Genetic analysis of A-factor synthesis inStreptomyces coelicolor A3(2) andStreptomyces griseus.Journal of General Microbiology 129, 2939–2944.Google Scholar
  18. Hopwood, D.A., Malpartida, F., Kieser, H.M.et al. 1985 Production of “hybrid” antibiotics by genetic engineering.Nature 314, 642.CrossRefGoogle Scholar
  19. Hopwood, D.A., Caballero, J., Fernandez, M., Martinez, E. & Malpartida, F. 1990a Organization of theactI region ofStreptomyces coelicolor. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC406.Google Scholar
  20. Hopwood, D.A., Sherman, D.H., Khosla, C. & Bibb, M.J. 1990b “Hybrid” pathways for the production of secondary metabolites. InAbstracts of the 6th International Symposium on Genetics of Industrial Microorganisms, Strasbourg, 12–18 August, 1990, FR, S6-4.Google Scholar
  21. Horinouchi, S. & Beppu, T. 1990 Regulation of secondary metabolism and morphogenesis inStreptomyces. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC008.Google Scholar
  22. Horinouchi, S., Harao, O. & Beppu, T. 1983 Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin inStreptomyces coelicolor A3(2) andStreptomyces lividans.Journal of Bacteriology 155, 1238–1248.Google Scholar
  23. Hutchinson, C.R., Engwall, K.J., Guifoile, P.G.et al. 1990 Properties of genes and enzymes for the biosynthesis of antitumor anthracycline antibiotics. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC009.Google Scholar
  24. Katz, L., Brown, D., Boris, K. & Tuan, J. 1987 Expression of the macrolide-lincosamide-streptogramin B-resistance methylase gene,ermE, fromStreptomyces erythreus inEscherichia coli results in N6-monomethylation and N6,N6-dimethylation of ribosomal RNA.Gene 55, 319–325.CrossRefGoogle Scholar
  25. Katz, L., Staver, M., Tuan, J., Brown, D. & Donadio, S. 1990 Genetics of erythromycin synthesis inSaccharopolyspora erythraea. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC010.Google Scholar
  26. Katz, L., Tuan, J.S., Weber, J.M.et al. 1988 Genetic studies on erythromycin biosynthesis inSaccharopolyspora erythrea. InAbstracts of the ASM Conference on the Genetics and Molecular Biology of Industrial Microorganisms. Bloomington, No. 07.Google Scholar
  27. Kessler, A., Dittrich, W., Betzler, M. & Schrempf, H. 1989 Cloning and analysis of a deletable tetracycline-resistance determinant ofStreptomyces lividans 1326.Molecular Microbiology 3, 1103–1109.Google Scholar
  28. Kuhstoss, S., Richardson, M.A. & Rao, R.N. 1989 Site-specific integration inStreptomyces ambofaciens: localization of integration functions inS. ambofaciens plasmid pSAM2.Journal of Bacteriology 171, 16–23.Google Scholar
  29. Linton, K.J. & Hunter, I.S. 1990 Resistance to, and biosynthesis of the polyetherionophore antibiotic tetronasin inS. long-isporoflavus. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC313.Google Scholar
  30. Lomovskaya, N.D., Sezonov, G.V., Chinenova, T.A., Isaeva, L.M. & Voeykova, T.A. 1990a Characterization and cloning ofStreptomyces aureofaciens resistance determinants InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC314.Google Scholar
  31. Lomovskaya, N.D., Sezonov, G.V., Chinenova, T.A., Isaeva, L.M. & Voeykova, T.A. 1990b Characterization and cloning ofStreptomyces aureofaciens mtr gene(s) for multiple inducible resistance to macrolides and chlortetracycline. InAbstracts of the 6th International symposium on Genetics of Industrial Microorganisms, Strasbourg, 12–18 August 1990, FR, A-60.Google Scholar
  32. Lomovskaya, N.D., Sezonov, G., Isaeva, L. & Chinenova, T. 1991 Genetic characterization and cloning of genes for chlortetracycline resistance inStreptomyces aureofaciens strains. InGenetic and Product Formation in Streptomyces, eds Baumberg, S. Kurgel, H. & Woack, D. New York: Plenum.Google Scholar
  33. MacNeil, D.J., Gewain, K.M., Ruby, C.L., MacNeil, T. & Gibbons, P.H. 1990 The genes for avermectin biosynthesis are clustered. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC013.Google Scholar
  34. Malpartida, F. & Hopwood, D.A. 1984 Molecular cloning of the whole biosynthetic pathway of aStreptomyces antibiotic and its expression in a heterologous host.Nature 309, 462–464.CrossRefGoogle Scholar
  35. Malpartida, F. & Hopwood, D.A. 1986 Physical and genetic characterization of the gene cluster for the antibiotic actinorhodin inStreptomyces coelicolor A3(2).Molecular and General Genetics 205, 66–73.CrossRefGoogle Scholar
  36. Malpartida, F., Hallam, S.E., Kieser, H.M & Hopwood, D.A. 1986 Organization of the actinorodin genes ofStreptomyces coelicolor and their use as probes to isolate other polyketide biosynthetic genes: implications for “hybrid” antibiotic production InFifth International Symposium on the GIM, eds Alacevicet al. pp. 29–40. Yugoslavia: Split.Google Scholar
  37. Malpartida, F., Hallam, S.E., Kieser, H.M.et al. 1987 Homology betweenStreptomyces genes coding for the synthesis of different polyketides used to clone antibiotic biosynthetic genes.Nature 325, 818–821.CrossRefGoogle Scholar
  38. Omer, C.A. & Cohen, S.N. 1986 Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element ofStreptomyces coelicolor.Journal of Bacteriology 166, 999–1006.Google Scholar
  39. Omura, S., Ikeda, H., Malpartida, F., Keiser, M. & Hopwood, D.A. 1986 Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain.Antimicrobial Agents Chemotherapy 29, 13–19.Google Scholar
  40. Reynes, J.P., Calmels, T., Drocourt, D & Tiraby, G. 1988 Cloning, expression inEscherichia coli and nucleotide sequence of a tetracycline-resistance gene fromStreptomyces rimosus.Journal of General Microbiology 134, 585–598.Google Scholar
  41. Richardson, M.A., Kuhstoss, S., Huber, M.et al. 1989 Cloning of genes involved in spiramycin biosynthesis fromStreptomyces ambofaciens. InGenetics and Molecular Biology of Industrial Microorganisms, eds Hershberger, C.L., Queener, S.W. & Hegeman, G., pp. 40–43. Washington: American Society for Microbiology.Google Scholar
  42. Sezonov, G.V., Krugel, G., Kudryashova, E.A., Kolibaba, L.G. & Lomovskaya, N.D. 1990 Cloning of the resistance genegsr and studying of its function in producer strainStreptomyces griseus Kr.Antibiotiki i chimioterapiya (USSR) 12, 14–17.Google Scholar
  43. Simonet, J.-M., Boccard, F., Peronodet, J.-L., Gagnat, J. & Guerineau, M. 1987 Excision and integration of a self-transmissible replicon ofStreptomyces ambofaciens.Gene 59, 137–144.CrossRefGoogle Scholar
  44. Sosio, M., Madon, J. & Hutter, R. 1989 Excision of pIJ408 from the chromosome ofStreptomyces glaucescens and its transfer intoStreptomyces lividans.Molecular and General Genetics 218, 169–176.CrossRefGoogle Scholar
  45. Stanzak, R., Matsushima P., Baltz, R.H. & Rao, R.N. 1986 Cloning and expression inStreptomyces lividans of clustered erythromycin biosynthesis genes fromStreptomyces erythreus.Biotechnology 4, 229–232.CrossRefGoogle Scholar
  46. Stein, D. & Cohen, S.N. 1989 A cloned regulatory gene ofStreptomyces lividans can suppress the pigment deficiency of phenotype of different developmental mutants.Journal of Bacteriology 171, 2258–2261.Google Scholar
  47. Streicher, S.L. 1988 Cloning genes for avermectin biosynthesis inStreptomyces avermitilis. InAbstracts of the ASM Conference on the Genetics and Molecular Biology of Industrial Microorganisms. Bloomington, No. 06.Google Scholar
  48. Weber, J.M. Wierman, C.K. & Hutchinson, C.R. 1985 Genetic analysis of erythromycin production inStreptomyces erythreus.Journal of Bacteriology 164, 425–433.Google Scholar
  49. Yiguang, W., Li, T., Xuewei, Z., Xiaoming, X., Ying, Z. & Hutchinson, C.R. 1990 Function of putative polyketide synthase genes from midecamycin and spiramycin producing strains inStreptomyces coelicolor actI andactIII mutants. InAbstracts: UCLA Symposium on Molecular and Cellular Biology, 19th Annual Meeting, CC325.Google Scholar

Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • N. D. Lomovskaya
    • 1
  • G. V. Sezonov
    • 1
  1. 1.Institute of Genetics and Selection of Industrial MicroorganismsMoscowRussia

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