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Archives of Gynecology and Obstetrics

, Volume 245, Issue 1–4, pp 149–154 | Cite as

Der immunologisch bedingte Abort — Diagnose und Therapie

  • M. von Ditfurth
  • B. M. E. Kuntz
  • U. Kuhn
  • W. Distler
Geburtshilfe, Materno-Fetale Medizin Immunologie der Schwangerschaft «Habitueller» Abort
  • 24 Downloads

Zusammenfassung

In der Schwangerschaft trägt die Mutter ein mit eigener Antigenität ausgestattetes, wachsendes Transplantat, den Embryo oder Fetus. Bei regelrechtem Schwangerschaftsverlauf bildet das maternale Immunsystem blokkierende Faktoren, so daß der Embryo einer Abstoßung durch den mütterlichen Organismus entgeht. Störungen des immunologischen Gleichgewichtes zwischen mütterlichem Immunsystem und Embryo führen zum immunologisch bedingten Abort. Die Diagnostik besteht in dem fehlenden Nachweis schwangerschafts-schützender Faktoren. Neuerdings kann bei den Patientinnen mit immunologisch bedingter Abortneigung eine spezifische Immuntherapie zur Abortprophylaxe durchgeführt werden.

Immunological factors in recurrent spontaneous abortion

Summary

As etiological factors responsible for repeated miscarriages disturbances of the maternal-fetal immunoregulation are involved. Diagnostic aspects of the immunobiology of abortion and the clinical management of habitual abortion by immunotherapy are discussed.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • M. von Ditfurth
    • 1
  • B. M. E. Kuntz
    • 2
  • U. Kuhn
    • 3
  • W. Distler
    • 1
  1. 1.Universitäts-Frauenklinik DüsseldorfDüsseldorfDeutschland
  2. 2.Institut für BlutgerinnungswesenUniversität DüsseldorfDüsseldorfDeutschland
  3. 3.Institut für ImmungenetikUniversitätsklinikum EssenEssenDeutschland

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