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Benzodiazepine receptor-mediated effect of CGS 8216 on milk consumption in the non-deprived rat

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Abstract

The pyrazoloquinoline CGS 8216, which binds with high affinity to central benzodiazepine recognition sites, produced a highly significant reduction in the consumption of familiar, sweetened milk by non-deprived male rats, when administered in a dose of 20 mg/kg, IP. The anorectic effect was present during the first 5 min period of a 20-min drinking test, and remained in evidence throughout the remainder of the test. The benzodiazepine receptor antagonist Ro15-1788, administered 15 min before the consumption test, produced a dose-related (10–40 mg/kg, IP) reversal of the anorectic effect of CGS 8216, during the first 10 min of the test. Injection of Ro15-1788 alone had no significant effect on milk ingestion. This experiment shows that the reduction in the consumption of a palatable liquid food by CGS 8216 can be attributed to an action at benzodiazepine receptors. The result is consistent with the characterization of CGS 8216 as a weak benzodiazepine receptor inverse agonist.

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Authors and Affiliations

  1. Department of Psychology, University of Birmingham, B15 2TT, Birmingham, UK

    Lorna B. Estall & Steven J. Cooper

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  1. Lorna B. Estall
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  2. Steven J. Cooper
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Estall, L.B., Cooper, S.J. Benzodiazepine receptor-mediated effect of CGS 8216 on milk consumption in the non-deprived rat. Psychopharmacology 89, 477–479 (1986). https://doi.org/10.1007/BF02412125

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  • DOI: https://doi.org/10.1007/BF02412125

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