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Calcified Tissue International

, Volume 34, Issue 1, pp 131–135 | Cite as

Serum calcium regulating hormones in the perinatal period

  • Yoshiki Seino
  • Makoto Ishida
  • Kanji Yamaoka
  • Tsuneyasu Ishii
  • Teisuke Hiejima
  • Chiiko Ikehara
  • Yoshiyuki Tanaka
  • Shunji Matsuda
  • Tsunesuke Shimotsuji
  • Hyakuji Yabuuchi
  • Shigeto Morimoto
  • Toshio Onishi
Article

Summary

To clarify perinatal vitamin D metabolism, we measured 25-hydroxyvitamin D (25OHD), 24,25-dihydroxyvitamin D [24,25(OH)2D], 1,25-dihydroxyvitamin D [1,25(OH)2D], calcium (Ca), phosphorus (P), parathyroid hormone (PTH), and human calcitonin (CT) in paired maternal, cord, and infant serum. Cord serum 25OHD was significantly lower than the maternal level, and cord serum 24,25(OH)2D was also significantly below the maternal concentrations. Maternal, cord, and infant serum 1,25(OH)2D, on the other hand, was significantly higher than the normal adult level. The serum PTH was low, but the CT concentration was high in the cord. Cord serum Ca and P levels were significantly higher than maternal. The reason for the elevated circulating 1,25(OH)2D level in the perinatal period is uncertain, and we speculate that the possible factors are gonadal steroids, placental lactogen, prolactin, and CT. In addition, serum 24,25(OH)2D and 1,25(OH)2D concentrations are under some control by the fetus.

Key words

25OHD 24,25 (OH)21,25 (OH)2Cord Infant 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Yoshiki Seino
    • 1
  • Makoto Ishida
    • 1
  • Kanji Yamaoka
    • 1
  • Tsuneyasu Ishii
    • 1
  • Teisuke Hiejima
    • 1
  • Chiiko Ikehara
    • 1
  • Yoshiyuki Tanaka
    • 1
  • Shunji Matsuda
    • 1
  • Tsunesuke Shimotsuji
    • 1
  • Hyakuji Yabuuchi
    • 1
  • Shigeto Morimoto
    • 2
  • Toshio Onishi
    • 2
  1. 1.Department of PediatricsOsaka University Hospital, Osaka University School of MedicineOsakaJapan
  2. 2.Department of Medicine and GeriatricsOsaka University Hospital, Osaka University School of MedicineOsakaJapan

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