Calcified Tissue International

, Volume 34, Issue 1, pp 21–28 | Cite as

Clinical usefulness of a bone mineral measurement method on the femoral shaft

  • Jean-Pierre Sabatier
  • Jean-François Héron
  • Jean-François Petiot
  • Noëlle Sabatier
  • Jean-Jacques Dronne


An improved version of a previously described photon absorptiometry method for measuring the bone mineral content of the femoral shaft is presented. The study included 267 healthy persons, who served as control subjects, and 31 osteoporotic and 3 osteomalacic female patients. A monoenergetic source of241Am was used and a fully automatic apparatus designed. The examinations were recorded with an independent microcomputer and secondarily processed by the nuclear unit central computer. The guidelines of Cameron and West were used to perform various calculations from the initial absorption curve, and the clinical usefulness of these was tested. On the one hand, cortical bone density (CBD) and bone linear attenuation coefficient (BLAC) were found adequately to differentiate between osteoporotics and controls, but we defined a discriminative function (F) which allowed even better separation between the two groups. On the other hand, bone index (BI) was found to be the best parameter to follow an individual patient during therapy. These results underline the usefulness of these calculations for detecting and monitoring the progress of pathological states.

Key words

Photon absorptiometry Cortical bone density Bone index Osteoporosis 


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  1. 1.
    Cohn, S. H., Aloia, J. F., Letteri, J. M.: Noninvasive measurements of bone mass and their clinical significance, Calcif. Tissue Res.26:1–3, 1978CrossRefPubMedGoogle Scholar
  2. 2.
    Cameron, J. R., Sorensen, J.: Measurement of bone mineral in vivo: an improved method, Science142:230–232, 1963PubMedGoogle Scholar
  3. 3.
    Christiansen, C., Rödbro, P.: Bone mineral content and estimated total body calcium in normal adults, Scand. J. Clin. Lab. Invest.35:433–439, 1975PubMedGoogle Scholar
  4. 4.
    Overton, T. R., Silverberg, D. S., Rigal, W. M., Friedenberg, L.: University of Alberta bone mineral analysis system. Performance and clinical application. In R. B. Mazess (ed.): International Conference on Bone Mineral Measurement, pp. 11–29. DHEW Publ. 75. 683, Washington, D.C., 1974Google Scholar
  5. 5.
    Nilson, B. E. R.: Post traumatic osteopenia: quantitative study of bone mineral in the femur following fracture of the tibia in man using241Am as a photon source, Acta Orthop. Scand.37:Suppl. 91, 1966Google Scholar
  6. 6.
    West, R. R.: The estimation of total skeletal mass from bone densitometry measurements using 60 KeV photons, Br. J. Radiol.46:599–603, 1973PubMedCrossRefGoogle Scholar
  7. 7.
    Héron, J. F., Sabatier, J. P., Bouvard, G., et al.: Densitométrie osseuse fémorale. Premiers résultats, J. Fr. Biophys. Med. Nucl.2:85–92, 1978Google Scholar
  8. 8.
    West, R. R.: Measurement of bone mineralization by radiation absorption methods: in vivo and in vitro studies. Thesis University of Leeds, England 1969Google Scholar
  9. 9.
    Horsman, A., Bulusu, L., Bentley, H. B., et al.: Internal relationships between skeletal parameters in twenty three male skeletons. In J. R. Cameron (ed.): International Conference on Bone Mineral Measurement, pp. 365–382. Chicago, 1973Google Scholar
  10. 10.
    Christiansen, C., Rödbro, P.: Estimation of total body calcium from the bone mineral content of the forearm, Scand. J. Clin. Lab. Invest.35:425–431, 1975PubMedGoogle Scholar
  11. 11.
    Meema, H. E., Taves, D. R., Oreopoulos, D. G.: Comparisons between X-ray photo densitometric and gamma-ray densitometric findings of bone mineral measurements, and the evidence of their convertibility, Invest. Radiol.11:550–555, 1976PubMedGoogle Scholar
  12. 12.
    Meema, H. E., Meema, S.: Compact bone mineral density of the normal human radius, Acta Radiol. Oncol. Radiat. Phys. Biol.17:343–352, 1978Google Scholar
  13. 13.
    Mazess, R. B., Cameron, J. R.: Bone mineral content in normal U.S. whites. In J. R. Cameron (ed.): International Conference on Bone Mineral Measurement, pp. 228–238, Chicago, 1973Google Scholar
  14. 14.
    Aloia, J. F., Cohn, S. H., Ross, P. et al.: Skeletal mass in postmenopausal women, Am. J. Physiol.235:E82-E87, 1978PubMedGoogle Scholar
  15. 15.
    Harrison, J. E., McNeill, K. G., Hitchman, A. J., et al.: Bone mineral measurements of the central skeleton by in vivo neutron activation analysis for routine investigation of osteopenia, Invest. Radiol.14:27–34, 1979PubMedGoogle Scholar
  16. 16.
    Smith, C. B., Smith, D. A.: Relations between age, mineral density and mechanical properties of human femoral compacta, Acta Orthop. Scand.47:496–502, 1976PubMedCrossRefGoogle Scholar
  17. 17.
    Moore, W. T., Shapiro, J. R., Jorgensen, H., et al.: The evaluation of bone density in normal populations and osteoporosis, Trans. Am. Clin. Climatol. Assoc.86:128–138, 1974Google Scholar
  18. 18.
    Meema, H. E., Meema, S.: Cortical bone mineral density versus cortical thickness in the diagnosis of osteoporosis: a roentgenologic densitometric study, J. Am. Geriatr. Soc.17:120–126, 1969PubMedGoogle Scholar
  19. 19.
    Manzke, E., Chesnut, C. H. III, Wergedal, J. E., et al.: Relationship between local and total bone mass in osteoporosis, Metabolism24:605–615, 1975CrossRefPubMedGoogle Scholar
  20. 20.
    Dalén, N., Jacobson, B.: Bone mineral assay. Choice of measuring sites, Invest. Radiol.9:174–185, 1974PubMedGoogle Scholar
  21. 21.
    Sorensen, J. A., Cameron, J. R.: A reliable in vivo measurement of bone mineral content, J. Bone Joint Surg.49-A:481–497, 1967Google Scholar
  22. 22.
    Christiansen, C., Rödbro, P., Jensen, H.: Bone mineral content in the forearm measured by photon absorptiometry. Principles and reliability, Scand. J. Clin. Lab. Invest.35:323–330, 1975PubMedGoogle Scholar
  23. 23.
    Christiansen, C., Rödbro, P.: Long-term reproducibility of bone mineral content measurements, Scand. J. Clin. Lab. Invest.37:321–323, 1977PubMedGoogle Scholar
  24. 24.
    Harmut, M., Rezaković, D., Matković, V.: Gamma absorptiometry of the forearm bone, Period. Biol.81:19–25, 1979Google Scholar
  25. 25.
    Sigmon, B. A.: Distribution of bone mineral in the femur. In J. R. Cameron (ed.): Proceedings of the Bone Measurement Conference, pp. 428–435. US Atomic energy commission Conf. 700515, 1970Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Jean-Pierre Sabatier
    • 1
  • Jean-François Héron
    • 1
  • Jean-François Petiot
    • 1
  • Noëlle Sabatier
    • 1
  • Jean-Jacques Dronne
    • 1
  1. 1.Departments of Nuclear Medicine, Rheumatology, and Medical StatisticsCaen University HospitalCaenFrance

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