Abstract
Plasma cyclic AMP is a “second messenger” that may reflect levels of activity of important neurotransmitter receptors. Plasma cyclic AMP was measured in 18 patients with childhood autism, 7 patients with pervasive developmental disorder, and 12 age- and sex-matched healthy controls. Plasma cyclic AMP was significantly elevated by over 100% in both groups of patients with childhood-onset psychoses compared with controls. Plasma cyclic GMP, a nucleotide linked to different receptors, was not elevated, suggesting that the finding may be specific.
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References
American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, D.C.
Belmaker, R. H., Hattab, J., Ebstein, R. P. (1978). Plasma dopamine-B hydroxylase in childhood psychoses.Journal of Autism and Childhood Schizophrenia, 8, 293–298.
Belmaker, R. H., Zohar, J., & Ebstein, R. P. (1980). Cyclic nucleotides in mental disorder. In P. Hamet & H. Sands (Eds.),Advances in cyclic nucleotide research (Vol. 12, pp. 187–197). New York: Raven Press.
Biederman, J., Rimon, R., Ebstein, R. P., Zohar, J., & Belmaker, R. H. (1976). Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients.Neuropsychobiology, 2, 324–327.
Broadus, A. E. (1977). Clinical cyclic nucleotide research.Advances in Cyclic Nucleotide Research, 8, 509–548.
Ebstein, R. P., Belmaker, R. H., Grunhaus, L., & Rimon, R. (1976). Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans.Nature, 259, 211–213.
Hoshino, Y., Kumashiro, H., Yashima, Y., Kaneko, M., Numata, Y., Oshima, N., & Watanabe, A. (1980). Plasma cyclic AMP level in psychiatric diseases in childhood.Folia Psychiatrica et Neurologica Japonica, 34, 9–16.
Lykouras, E., Varsou, E., Garelis, E., Stefanis, C. N., & Malliaras, D. (1978). Plasma cyclic AMP in manic-depressive illness.Acta Psychiatrica Scandinavica, 57, 447–53.
Lykouras, E., Varsou, E., Rinieris, P., & Stefanis, C. N. (1980). Plasma cyclic AMP in schizophrenics.Progress in Neuropsychopharmacology, 4, 69–74.
Palmer, G. C., & Duszynski, C. R. (1975). Regional cyclic GMP content in incubated tissue of rat brain.European Journal of Pharmacology, 32, 375–379.
Zohar, J., Rimon, R., Biederman, J., Ebstein, R. P., & Belmaker, R. H. (1978). Clinical correlates of CSF cyclic nucleotides in schizophrenia.American Journal of Psychiatry, 135, 253–255.
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Goldberg, M., Hattab, J., Meir, D. et al. Plasma cyclic AMP and cyclic GMP in childhood-onset psychoses. J Autism Dev Disord 14, 159–164 (1984). https://doi.org/10.1007/BF02409658
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DOI: https://doi.org/10.1007/BF02409658