Calcified Tissue International

, Volume 33, Issue 1, pp 361–363 | Cite as

Total body bone mineral and lean body mass by dual-photon absorptiometry

II. Comparison with total body calcium by neutron activation analysis
  • B. Mazess
  • Walter W. Peppler
  • Charles H. ChesnutIII
  • Wil B. Nelp
  • Stanton H. Cohn
  • Italo Zanzi


Total body bone mineral (TBBM) was measured in vivo using dual-photon absorptiometry (DPA) in 10 subjects. The total body calcium (TBCa) was measured in the same subjects using neutron activation analysis. The correlation between the two methods was very high (r>0.99) and the standard error of estimate was low. The TBCa relative to TBBM was about 39%. The two noninvasive methods provided nearly identical indications of skeletal mass, but the radiation exposure with DPA was 500 to 5000 times smaller (0.6 mrem vs 300 to 3000 mrem). The radius shaft bone mineral content was highly correlated with the TBBM (0.97) and the TBCa (0.98) and could be used to estimate the latter variables with errors (1 SEE) of 9% and 6%, respectively.

Key words

Bone mineral Body composition Absorptiometry 153Gd Skeletal measurement Neutron activation 


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  1. 1.
    Peppler, W., Mazess, R. B.: Total body bone mineral and lean body mass by dual-photon absorptiometry. I. Theory and measurement procedure, Calcif. Tissue Int.33:353–359, 1981Google Scholar
  2. 2.
    Mazess, R. B., Peppler, W.: Total body bone mineral by photon absorptiometry, Calif. Tissue Res. [Suppl.]22:452–453, 1977Google Scholar
  3. 3.
    Woodard, H. Q.: The composition of human cortical bone: effect of age and of some abnormalities, Clin. Orthop.37:187–193, 1964PubMedGoogle Scholar
  4. 4.
    Palmer, H. E., Nelp, W. B., Murano R., et al.: The feasibility ofin vivo neutron activation analysis of total body calcium and other elements of body composition, Phys. Med. Biol.13:269–279, 1968CrossRefPubMedGoogle Scholar
  5. 5.
    Williams, E. D., Boddy, K., Harvey, I., et al.: Calibration and evaluation of a system for total bodyin vivo activation analysis using 14 MeV neutrons, Phys. Med. Biol.23:405–415, 1978CrossRefPubMedGoogle Scholar
  6. 6.
    Nelp, W. B., Palmer, H. E., Murano, R., et al.: Measurement of total body calcium (bone mass) in vivo with the use of total body neutron analysis, J. Lab. Clin. Med.76:151–162, 1970PubMedGoogle Scholar
  7. 7.
    Nelp, W. B., Denney, J. D., Murano, R., et al.: Absolute measurements of total body calcium (bone mass) in vivo, J. Lab. Clin. Med.79:430–438, 1972PubMedGoogle Scholar
  8. 8.
    Manzke, E., Chesnut, C. H., Wergedal, J. E., et al.: Relationship between local and total bone mass in osteoporosis, Metabolism24:605–615, 1975CrossRefPubMedGoogle Scholar
  9. 9.
    Cohn, S. H., Shukla, K. K., Dombrowski, C. S., et al.: Design and calibration of a “broad-beam”: 238-Pu, Be neutron source for total-body neutron activation analysis, J. Nucl. Med.13:487–492, 1972PubMedGoogle Scholar
  10. 10.
    Aloia, J. F., Vaswani, A., Atkins, H., et al.: Radiographic morphometry and osteopenia in spinal osteoporosis, J. Nucl. Med.18:425–431, 1977PubMedGoogle Scholar
  11. 11.
    Cameron, J. R., Sorenson, J. A.: Measurement of bone mineralin vivo: an improved method, Science143:230–232, 1963Google Scholar
  12. 12.
    Mazess, R. B., Cameron, J. R., Miller, H.: Direct readout of bone mineral content using radionuclide absorptiometry, Int. J. Appl. Rad. Isot.23:471–479, 1972CrossRefGoogle Scholar
  13. 13.
    Mazess, R. B.: Estimation of bone and skeletal weight by direct photon absorptiometry, Invest. Radiol.6:52–60, 1971PubMedGoogle Scholar
  14. 14.
    Christiansen, C., Rodbro, P.: Estimation of total body calcium from the bone mineral content of the forearm, Scand. J. Clin. Lab. Invest.35:425–431, 1975PubMedGoogle Scholar
  15. 15.
    Horsmann, A., Bulusu, L., Bentley, H. B., et al.: Internal relationships between skeletal parameters in twenty-three male skeletons. In J. R. Cameron (ed.): Proc. Bone Measurement Conference. U.S. Atomic Energy Comm. Conf. 700515Google Scholar
  16. 16.
    Cohn, S. H., Ellis, K. J., Caselnova, R. C., et al.: Correlation of radial bone mineral content and total body calcium in chronic renal failure, J. Lab. Clin. Med.86:910–919, 1975PubMedGoogle Scholar
  17. 17.
    Cohn, S. H., Ellis, K. J., Wallach, S., et al.: Absolute and relative deficit in total-skeletal calcium and radial bone mineral in osteoporosis, J. Nucl. Med.15:428–435, 1974PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • B. Mazess
    • 1
  • Walter W. Peppler
    • 1
  • Charles H. ChesnutIII
    • 2
  • Wil B. Nelp
    • 2
  • Stanton H. Cohn
    • 3
  • Italo Zanzi
    • 3
  1. 1.Department of Radiology (Medical Physics)University of WisconsinMadison
  2. 2.Division of Nuclear MedicineUniversity Hospital, University of Washington, School of MedicineSeattle
  3. 3.Medical Research CenterBrookhaven National LaboratoryUptonUSA

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