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Calcified Tissue International

, Volume 33, Issue 1, pp 191–194 | Cite as

Action of vitamin D metabolites on PTH secretion in man

  • L. Miravet
  • J. Guéris
  • J. Redel
  • A. Norman
  • A. Ryckewaert
Clinical Investigation

Summary

We have examined the effects of metabolites of vitamin D [25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, and 25,26(OH)2D3] on serum calcium and iPTH in human deficient-D osteomalacia. The four metabolites decreased iPTH, but only for 1,25(OH)2D3 was a significant correlation between increase of serum calcium and decrease of iPTH observed. The 24,25(OH)2D3 and 25,26(OH)2D3 decreased iPTH despite a decrease of serum calcium at the beginning of treatment. The 25OHD decreased iPTH before increased serum calcium.

These results could be interpreted as a direct effect of metabolites of vitamin D on PTH secretion. However, the conversion of other metabolites and the calcium concentration in parathyroid cells must be determined before this hypothesis can be accepted.

Key words

25-Hydroxycholecalciferol 1,25 Dihydroxycholecalciferol 24,25-Dihydroxycholecalciferol 25,26-Dihydroxycholecalciferol 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • L. Miravet
    • 1
  • J. Guéris
    • 1
  • J. Redel
    • 2
  • A. Norman
    • 3
  • A. Ryckewaert
    • 1
  1. 1.Unité de Recherches sur le Métabolisme PhosphocalciqueU.18 et Clinique Rhumatologique de l'Hôpital LariboisièreParisFrance
  2. 2.Centre de Recherches sur les Maladies Ostéoarticulaires, U.5 INSERM-ERA CNRSHôpital CochinParisFrance
  3. 3.Department of BiochemistryUniversity of CaliforniaRiversideUSA

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