Summary
In order to evaluate the influence of bone mineralization on collagen metabolism, the bone collagen crosslinks were determined in femur diaphyses of mice with X-linked hypophosphatemia and of control littermates. No quantititative difference could be elicited between the two groups. It was also noted that in the mouse, cortical bone maturation is accompanied by a slight increase in the number of reducible crosslinks.
Similar content being viewed by others
References
Rasmussen, H., Anast, C.: Familial hypophosphatemic (vitamin D-resistant) rickets and vitamin D-dependent rickets. In J.B. Stanbury, J.B. Wyngaarden and D.S. Frederickson (eds): The Metabolic Basis of Inherited Disease, pp. 1537–1562. McGraw-Hill, New York, 1978
Eicher, E.M., Southard, J.L., Scriver, C.R., Glorieux, F.H.: Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets, Proc. Nat. Acad. Sci.73:4667–4671, 1976
Tenenhouse, H.S., Scriver, C.R., McInnes, R.R., Glorieux, F.H.: Renal handling of phosphate in vivo and in vitro by the X-linked hypophosphatemic male mouse (Hyp/y). Evidence for a defect in the brush border membrane, Kidney Intern.16:236–244, 1978
Marie, P.J., Travers, R., Glorieux, F.H.: Effects of phosphate and 1,25-dihydroxycholecalciferol on bone in the hypophosphatemic male mouse, Calcif. Tissue Intern.28:158, 1979
Tanzer, M.L.: Crosslinking of collagen, Science180:561–566, 1973
Robins, S.P., Shikodawaki, M., Bailey, A.J.: The chemistry of the collagen crosslinks: Age-related changes in the reducible components of intact bovine collagen fibers, Biochem. J.131:771–780, 1973
Mechanic, G., Tanzer, M.L.: Biochemistry of collagen crosslinking. Isolation of a new crosslink hydroxylysinohydroxynoleucine and its reduced precursor, dihydroxynorleucine, from bovine tendon, Biochem. Biophys. Res. Comm.41:1597–1604, 1970
Paz, M.A., Henson, E., Ronbauer, R., Abrash, L., Blumenfeld, O.O., Gallop, P.M.: α-amino alcohols as products of a reductive side reaction of denatured collagen with sodium borohydride, Biochemistry9:2123–2127, 1970
Mechanic, G.L.: A two column system for complete resolution of NaBH4 reduced crosslinks from collagen, Anal. Biochem.61:355–361, 1974
Mechanic, G.L.: Maturation of chick bone collagen and quantification of its structural crosslinks: Vitamin D status and cohesiveness of the collagen macromolecular matrix. In S.P. Nielsen, E. Hjorting-Hansen (eds.): Calcified Tissues 1975, pp. 177–184, Fadl's Forlag, Copenhagen, 1975
Dickson, I.R., Eyre, D.R., Kodicek, E.: Influence of plasma calcium and vitamin D on bone collagen. Effects of lysine hydroxylation and crosslink formation, Biochem. Biophys. Acta588:169–173, 1979
Jande, S.S., Dickson, I.R.: A comparative histological study of the effects of high calcium diet and vitamin D supplements on ephiphyseal plates of vitamin D deficient chicks, Acta Anatomica,in the press
Barnes, M.J., Constable, B.J., Morton, L.F., Kodicek, E.: Bone collagen metabolism in vitamin D deficiency, Biochem. J.132:113–115, 1973
van der Rest, M., Cole, W.G., Glorieux, F.H.: Human collagen "fingerprints" produced by clostridiopeptidase A digestion and high-pressure liquid chromatography, Biochem. J.161:527–538, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van der Rest, M., de Miguel, E. & Glorieux, F.H. The collagen crosslinking in the hypophosphatemic male mouse. Calcif Tissue Int 33, 77–79 (1981). https://doi.org/10.1007/BF02409415
Issue Date:
DOI: https://doi.org/10.1007/BF02409415