Skip to main content

Advertisement

Log in

The collagen crosslinking in the hypophosphatemic male mouse

  • Rapid Communication
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Summary

In order to evaluate the influence of bone mineralization on collagen metabolism, the bone collagen crosslinks were determined in femur diaphyses of mice with X-linked hypophosphatemia and of control littermates. No quantititative difference could be elicited between the two groups. It was also noted that in the mouse, cortical bone maturation is accompanied by a slight increase in the number of reducible crosslinks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Rasmussen, H., Anast, C.: Familial hypophosphatemic (vitamin D-resistant) rickets and vitamin D-dependent rickets. In J.B. Stanbury, J.B. Wyngaarden and D.S. Frederickson (eds): The Metabolic Basis of Inherited Disease, pp. 1537–1562. McGraw-Hill, New York, 1978

    Google Scholar 

  2. Eicher, E.M., Southard, J.L., Scriver, C.R., Glorieux, F.H.: Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets, Proc. Nat. Acad. Sci.73:4667–4671, 1976

    CAS  PubMed  Google Scholar 

  3. Tenenhouse, H.S., Scriver, C.R., McInnes, R.R., Glorieux, F.H.: Renal handling of phosphate in vivo and in vitro by the X-linked hypophosphatemic male mouse (Hyp/y). Evidence for a defect in the brush border membrane, Kidney Intern.16:236–244, 1978

    Google Scholar 

  4. Marie, P.J., Travers, R., Glorieux, F.H.: Effects of phosphate and 1,25-dihydroxycholecalciferol on bone in the hypophosphatemic male mouse, Calcif. Tissue Intern.28:158, 1979

    Google Scholar 

  5. Tanzer, M.L.: Crosslinking of collagen, Science180:561–566, 1973

    CAS  PubMed  Google Scholar 

  6. Robins, S.P., Shikodawaki, M., Bailey, A.J.: The chemistry of the collagen crosslinks: Age-related changes in the reducible components of intact bovine collagen fibers, Biochem. J.131:771–780, 1973

    CAS  PubMed  Google Scholar 

  7. Mechanic, G., Tanzer, M.L.: Biochemistry of collagen crosslinking. Isolation of a new crosslink hydroxylysinohydroxynoleucine and its reduced precursor, dihydroxynorleucine, from bovine tendon, Biochem. Biophys. Res. Comm.41:1597–1604, 1970

    Article  CAS  PubMed  Google Scholar 

  8. Paz, M.A., Henson, E., Ronbauer, R., Abrash, L., Blumenfeld, O.O., Gallop, P.M.: α-amino alcohols as products of a reductive side reaction of denatured collagen with sodium borohydride, Biochemistry9:2123–2127, 1970

    Article  CAS  PubMed  Google Scholar 

  9. Mechanic, G.L.: A two column system for complete resolution of NaBH4 reduced crosslinks from collagen, Anal. Biochem.61:355–361, 1974

    Article  CAS  PubMed  Google Scholar 

  10. Mechanic, G.L.: Maturation of chick bone collagen and quantification of its structural crosslinks: Vitamin D status and cohesiveness of the collagen macromolecular matrix. In S.P. Nielsen, E. Hjorting-Hansen (eds.): Calcified Tissues 1975, pp. 177–184, Fadl's Forlag, Copenhagen, 1975

    Google Scholar 

  11. Dickson, I.R., Eyre, D.R., Kodicek, E.: Influence of plasma calcium and vitamin D on bone collagen. Effects of lysine hydroxylation and crosslink formation, Biochem. Biophys. Acta588:169–173, 1979

    CAS  PubMed  Google Scholar 

  12. Jande, S.S., Dickson, I.R.: A comparative histological study of the effects of high calcium diet and vitamin D supplements on ephiphyseal plates of vitamin D deficient chicks, Acta Anatomica,in the press

  13. Barnes, M.J., Constable, B.J., Morton, L.F., Kodicek, E.: Bone collagen metabolism in vitamin D deficiency, Biochem. J.132:113–115, 1973

    CAS  PubMed  Google Scholar 

  14. van der Rest, M., Cole, W.G., Glorieux, F.H.: Human collagen "fingerprints" produced by clostridiopeptidase A digestion and high-pressure liquid chromatography, Biochem. J.161:527–538, 1977

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

van der Rest, M., de Miguel, E. & Glorieux, F.H. The collagen crosslinking in the hypophosphatemic male mouse. Calcif Tissue Int 33, 77–79 (1981). https://doi.org/10.1007/BF02409415

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02409415

Key words

Navigation