Abstract
One usually thinks of ionic flow across membranes as controlled by modulation of the energies needed by an ion to get into a membrane. Examination of these energies shows that they are not only large enough to perturb the ionic distribution but also sufficient to deform a thin membrane. The deformability of a cell membrane may then be related to its control of ionic current.
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Caplan, S. R., and Mikulecky, D. C. Transport processes in membranes. In J. A. Marinsky (Ed.),Ion exchange. New York: Dekker, 1966. Vol. 1.
Cole, K. S.Membranes, ions and impulses. Berkeley: University of California Press, 1968. P. 569.
Ehrenstein, G., Blumenthal, R., LaTorre, R., and Lecar, H.Journal of General Physiology 1974,63, 107.
Ehrenstein, G., and Lecar, H. The mechanism of signal transmission in nerve axons.Annual Review of Biophysics and Bioengineering 1972,1, 347.
Ehrenstein, G., Lecar, H., and Nossal, R.Journal of General Physiology 1970,55, 119.
Eisenman, G., Szabo, G., Ciani, S., McLaughlin, S. G. A., and Krasne, S. Ion bonding and ion transport processed by neutral lipid-soluble molecules. In J. F. Danielli (Ed.),Progress in surface and membrane sciences. New York: Academic Press, 1973. Vol. 6, p. 139.
Eisenman, G., Szabo, G., McLaughlin, S. G. A., and Ciani, S. M. In E. Munos, F. Garcia-Fernandiz, D. Vazques (Eds.),Molecular mechanisms of antibiotic action on protein biosynthesis and membranes. Amsterdam: Elsevier, 1972.
Finkelstein, A. Aqueous pores created in thin lipid membranes by the antibiotics nystatin, amphotericin B and gramicidin-A: Implications for pores in plasma membranes. In B. A. Callingham (Ed.),Drugs and transport properties. London: Macmillian, 1974, Pp. 241–250.
Gibbs, J. W.The scientific papers of J. W. Gibbs. Vol. 1.Thermodynamics. New York: Dover, 1961, P. 425.
Hall, J. E., Mead, C. A., and Szabo, G.Journal of Membrane Biology 1973,11, 75.
Haydon, D. A., and Hladky, S. B.Quarterly Reviews of Biophysics 1972,5, 187.
Hladky, S. B., Gordon, L. G. M., and Haydon, D. A. Molecular mechanisms of ion transport in lipid membranes.Annual Review of Physical Chemistry 1974,25, 11.
Hodgkin, A. L.The conduction of the nervous impulse. Springfield, Ill.: Thomas, 1964. P. 108.
Jain, M. K.The bimolecular lipid membrane: A system. New York: Van Nostrand, Reinhold, 1972.
Katchalsky, A., and Curran, P.Non-equilibrium thermodynamics in biophysics. Cambridge, Mass.: Harvard University Press, 1965.
Katz, B.Nerve, muscle and synapse. New York: McGraw-Hill, 1966, P. 193.
Lauger, P.Biochimica et Biophysica Acta 1973,311, 423.
Lauger, P., and Stark, G. Kinetics of carrier-mediated ion transport across lipid bilayer membranes.Biochimica et Biophysica Acta 1970,211, 458.
Mikulecky, D. C. In H. J. M. Hanley (Ed.),Biological aspects of transport in transport phenomena in flulas. New York: Dekker, 1969. Chap. 12, p. 433.
Mueller, P., and Rudin, D. O. Action potential phenomena in experimental biomolecular lipid membranes.Nature (London) 1967,213, 603.
Mueller, P., and Rudin, D. O. Action potentials in biomolecular lipid membranes.Nature (London) 217, 713. (No date.)
Mueller, P., Rudin, D. O., Tien, H. T., and Wescott, W. C. Formation and properties of biomolecular lipid membranes. In J. F. Danielli and A. C. Riddiford (Eds.),Recent progress in surface sciences. 1964. Vol. 1, chap. 2, p. 379.
Neumcke, B., and Lauger, P.Biophysical Journal 1969,9, 1160.
Parsegian, V. A. Energy of an ion crossing a low dielectric membrane: Solutions to four relevant electrostatic problems.Nature (London) 1969,221, 844.
Parsegian, V. A. Ion-lipid repulsions as structural forces.Annals of the New York Academy of Sciences, 1975,264, 461.
Szabo, G., Eisenman, G., Laprade, R., Ciani, S. M., and Krasne, S. In G. Eisenman (Ed.),Membranes, New York: Dekker, 1973, 1973. P. 17a.
Tasaki, I.Nerve excitation. Springfield, Ill.: Thomas, 1968. P. 201.
Taylor, R. E. Excitable membranes.Annual Review of Physical Chemistry 1974,25, 387.
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Parsegian, V.A. A comment on models of ion transport across cell membranes. Ann Biomed Eng 3, 433–438 (1975). https://doi.org/10.1007/BF02409327
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DOI: https://doi.org/10.1007/BF02409327