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A comment on models of ion transport across cell membranes

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Abstract

One usually thinks of ionic flow across membranes as controlled by modulation of the energies needed by an ion to get into a membrane. Examination of these energies shows that they are not only large enough to perturb the ionic distribution but also sufficient to deform a thin membrane. The deformability of a cell membrane may then be related to its control of ionic current.

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References

  • Caplan, S. R., and Mikulecky, D. C. Transport processes in membranes. In J. A. Marinsky (Ed.),Ion exchange. New York: Dekker, 1966. Vol. 1.

    Google Scholar 

  • Cole, K. S.Membranes, ions and impulses. Berkeley: University of California Press, 1968. P. 569.

    Google Scholar 

  • Ehrenstein, G., Blumenthal, R., LaTorre, R., and Lecar, H.Journal of General Physiology 1974,63, 107.

    Article  Google Scholar 

  • Ehrenstein, G., and Lecar, H. The mechanism of signal transmission in nerve axons.Annual Review of Biophysics and Bioengineering 1972,1, 347.

    Article  CAS  PubMed  Google Scholar 

  • Ehrenstein, G., Lecar, H., and Nossal, R.Journal of General Physiology 1970,55, 119.

    Article  CAS  PubMed  Google Scholar 

  • Eisenman, G., Szabo, G., Ciani, S., McLaughlin, S. G. A., and Krasne, S. Ion bonding and ion transport processed by neutral lipid-soluble molecules. In J. F. Danielli (Ed.),Progress in surface and membrane sciences. New York: Academic Press, 1973. Vol. 6, p. 139.

    Google Scholar 

  • Eisenman, G., Szabo, G., McLaughlin, S. G. A., and Ciani, S. M. In E. Munos, F. Garcia-Fernandiz, D. Vazques (Eds.),Molecular mechanisms of antibiotic action on protein biosynthesis and membranes. Amsterdam: Elsevier, 1972.

    Google Scholar 

  • Finkelstein, A. Aqueous pores created in thin lipid membranes by the antibiotics nystatin, amphotericin B and gramicidin-A: Implications for pores in plasma membranes. In B. A. Callingham (Ed.),Drugs and transport properties. London: Macmillian, 1974, Pp. 241–250.

    Google Scholar 

  • Gibbs, J. W.The scientific papers of J. W. Gibbs. Vol. 1.Thermodynamics. New York: Dover, 1961, P. 425.

    Google Scholar 

  • Hall, J. E., Mead, C. A., and Szabo, G.Journal of Membrane Biology 1973,11, 75.

    CAS  Google Scholar 

  • Haydon, D. A., and Hladky, S. B.Quarterly Reviews of Biophysics 1972,5, 187.

    CAS  PubMed  Google Scholar 

  • Hladky, S. B., Gordon, L. G. M., and Haydon, D. A. Molecular mechanisms of ion transport in lipid membranes.Annual Review of Physical Chemistry 1974,25, 11.

    Article  CAS  Google Scholar 

  • Hodgkin, A. L.The conduction of the nervous impulse. Springfield, Ill.: Thomas, 1964. P. 108.

    Google Scholar 

  • Jain, M. K.The bimolecular lipid membrane: A system. New York: Van Nostrand, Reinhold, 1972.

    Google Scholar 

  • Katchalsky, A., and Curran, P.Non-equilibrium thermodynamics in biophysics. Cambridge, Mass.: Harvard University Press, 1965.

    Google Scholar 

  • Katz, B.Nerve, muscle and synapse. New York: McGraw-Hill, 1966, P. 193.

    Google Scholar 

  • Lauger, P.Biochimica et Biophysica Acta 1973,311, 423.

    CAS  PubMed  Google Scholar 

  • Lauger, P., and Stark, G. Kinetics of carrier-mediated ion transport across lipid bilayer membranes.Biochimica et Biophysica Acta 1970,211, 458.

    CAS  PubMed  Google Scholar 

  • Mikulecky, D. C. In H. J. M. Hanley (Ed.),Biological aspects of transport in transport phenomena in flulas. New York: Dekker, 1969. Chap. 12, p. 433.

    Google Scholar 

  • Mueller, P., and Rudin, D. O. Action potential phenomena in experimental biomolecular lipid membranes.Nature (London) 1967,213, 603.

    CAS  Google Scholar 

  • Mueller, P., and Rudin, D. O. Action potentials in biomolecular lipid membranes.Nature (London) 217, 713. (No date.)

  • Mueller, P., Rudin, D. O., Tien, H. T., and Wescott, W. C. Formation and properties of biomolecular lipid membranes. In J. F. Danielli and A. C. Riddiford (Eds.),Recent progress in surface sciences. 1964. Vol. 1, chap. 2, p. 379.

  • Neumcke, B., and Lauger, P.Biophysical Journal 1969,9, 1160.

    CAS  PubMed  Google Scholar 

  • Parsegian, V. A. Energy of an ion crossing a low dielectric membrane: Solutions to four relevant electrostatic problems.Nature (London) 1969,221, 844.

    CAS  Google Scholar 

  • Parsegian, V. A. Ion-lipid repulsions as structural forces.Annals of the New York Academy of Sciences, 1975,264, 461.

    Google Scholar 

  • Szabo, G., Eisenman, G., Laprade, R., Ciani, S. M., and Krasne, S. In G. Eisenman (Ed.),Membranes, New York: Dekker, 1973, 1973. P. 17a.

    Google Scholar 

  • Tasaki, I.Nerve excitation. Springfield, Ill.: Thomas, 1968. P. 201.

    Google Scholar 

  • Taylor, R. E. Excitable membranes.Annual Review of Physical Chemistry 1974,25, 387.

    Article  CAS  Google Scholar 

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Parsegian, V.A. A comment on models of ion transport across cell membranes. Ann Biomed Eng 3, 433–438 (1975). https://doi.org/10.1007/BF02409327

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  • DOI: https://doi.org/10.1007/BF02409327

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