Dinucleotides and G + C content in human genes: Opposite behavior of GpG, GpC, and TpC at II-III codon positions and in introns
- 42 Downloads
AA, AC, CC, CT, and GA, doublets showing no difference between introns and II-III codon positions in the full range of G + C variation
TG and TA, which differ in the full range of G + C variation
AT, AG, GT, TC, TT, GG, GC, CG, and CA, which show differences in regions over 50% G + C
A remarkable pattern observed concerns the behavior of GG, GC, and TC, which showed opposite trends in II-III codon positions and in introns. If codon positions and introns are under the same structural requirements and the same mutational bias, our results indicate that the differences observed could be related to post-transcriptional constraints acting on mRNA.
Key wordsHuman genome Dinucleotides Introns II-III codon positions G + C content
Unable to display preview. Download preview PDF.
- Dixon WJ, Brown MB (1979) BMDP-79 biomedical computer programmes P series. University of California Press, BerkeleyGoogle Scholar
- Nussinov R (1980) Some rules in the ordering of nucleotides in the DNA. Nucleic Acids Res 19:4545–4562Google Scholar
- Wada K-N, Watanabe I, Tsuchiya R, Ikemura T (1991) G + C% mosaic structures of the higher vertebrate genome and distribution of dinucleotide frequencies. In: Kimura M, Nakahata T (eds) New aspects of the genetics of molecular evolution. Japan Sci Soc Press, Tokyo/Springer-Verlag, Berlin, pp 195–210Google Scholar