Calcified Tissue International

, Volume 36, Issue 1, pp 266–268 | Cite as

Vitamin D deficiency in mothers of rachitic infants

  • Abdelwahab T. H. Elidrissy
  • Saleh H. Sedrani
  • David E. M. Lawson
Clinical Investigations

Summary

The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months. 25-Hydroxyvitamin D (25OHD) levels were found to be low in mothers of the rachitic infants. This maternal deficiency as a factor in pathogenesis of rickets in the infant is discussed. Proposals are made to prevent the occurrence of rickets on this scale.

Key words

Rickets 25-Hydroxyvitamin D (25OHD) Vitamin D deficiency 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Elidrissy ATH, Taha SA (1980) Rickets in Riyadh. Proceeding of 5th Saudi Medical Meeting 409–418Google Scholar
  2. 2.
    Belton NR, Elidrissy ATH, Gaefer TH, Aldrees A, El-Swailem AR, Forfar JO, Barr DGD (1982) Maternal vitamin D deficiency as a factor in the pathogenesis of rickets in Saudi Arabia. In: Norman AW (ed) Biochemical and clinical endocrinology of calcium metabolism. Walter de Gruyler, Berlin, New York 735–737Google Scholar
  3. 3.
    Elidrissy ATH, Serinius F, El-Swailem AR, Dandona P (1983) Perinatal vitamin D and its relation to infantile rickets. Symposium Clinical Disorders of Calcium Metabolism (abstract), DetroitGoogle Scholar
  4. 4.
    Edelstein S, Charmoan M, Lawson DEM, Kodicek E (1974) Competitive binding assay for 25-hydroxycholecalciferol. Clin Sci Mol Med 46:231–236PubMedGoogle Scholar
  5. 5.
    Woodhouse NJY, Norton WL (1982) Low vitamin D levels in Saudi Arabians. King Faisal Specialist Hospital Medical Journal 2(3) 127–131Google Scholar
  6. 6.
    Harrison HE, Harrison HC (1979) Hypocalcaemic states in disorders of calcium and phosphate metabolism in childhood and adolescence. WB Saunders, Philadelphia p 89Google Scholar
  7. 7.
    Moncrief M, Fedahursi T (1974) Congenital rickets due to maternal vitamin D deficiency. Arch Dis Child 49:810–811CrossRefGoogle Scholar
  8. 8.
    Ford JA, Davidson DC, McIntosh WB, Fyfe WM, Dunningan MG (1973) Neonatal rickets in Asian immigrant population. Br Med J 3:211–212PubMedCrossRefGoogle Scholar
  9. 9.
    Heckmatt JO, Peacock M, Davies AE, McMurray J, Isherwood DM (1979) Plasma 25 hydroxyvitamin D in pregnant Asian women and their babies. Lancet 3:546–549CrossRefGoogle Scholar
  10. 10.
    Greer FR, Ho M, Dodson D, Tsang RC (1981) Lack of 25-hydroxyvitamin D and 1,25 dihydroxyvitamin D in human milk. J Pediatr 99:2:233–235CrossRefPubMedGoogle Scholar
  11. 11.
    Lakdowala DR, Widdowson EM (1977) Vitamin D in human milk. Lancet 167–168Google Scholar
  12. 12.
    Finberg L (1981) Human milk feeding and Vitamin D supplementation. J Pediatr 99:2:228–229CrossRefPubMedGoogle Scholar
  13. 13.
    Greer FR, Reave LE, Chesney RW, De Luca HF (1982) Water-soluble vitamin D in human milk: a myth. Pediatrics 69:2:238PubMedGoogle Scholar
  14. 14.
    Lawson DEM (1980) Metabolism of vitamin in vitamin D molecular biology and clinical nutrition. AW Norman Mercel Dekker, p 101Google Scholar
  15. 15.
    Birkbeck JA, Scott HF 25-hydroxycholecalciferol serum levels in breast-fed infants. Arch Dis Child 55:691–695Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Abdelwahab T. H. Elidrissy
    • 1
  • Saleh H. Sedrani
    • 2
  • David E. M. Lawson
    • 3
  1. 1.College of MedicineKing Saud UniversityRiyadhSaudi Arabia
  2. 2.College of ScienceKing Saud UniversityRiyadhSaudi Arabia
  3. 3.MRC Dunn Nutritional LaboratoryCambridgeEngland, U.K.

Personalised recommendations