Summary
The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of99mTc-MDP and blood flow in normal canine tibia. The findings, consistent with the model of capillary action proposed for muscle by Renkin and Crone, are applicable to bone. There is no evidence that in normal bone the surface area available for exchange responds to an increase in bone blood flow.
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References
Shim SS (1968) Physiology of blood flow in bone. J Bone Joint Surg [Br] 50A:812–818
Hughes SPF, Khan R, Davies R, Lavender JP (1978) The uptake by the canine tibia of the bone scanning agent99mTc-MDP before and after an osteotomy. J Bone Joint Surg [Br] 60B:579–582
Lavender JP, Khan R, Hughes SPF (1979) Blood flow and tracer uptake in normal and abnormal canine bone. J Nucl Med 20:413–418
Charkes ND (1980) Skeletal blood flow: implications for bone scan interpretation. J Nucl Med 21:91–98
McCarthy ID, Boland P, Khan R, Hughes SPF (Submitted) Clearance and flow changes in the fractured canine tibia. Clin Ortho Rel Res 1982
King MA, Casarett GW, Weber DA (1979) A study of irradiated bone: histopathological and physiological changes. J Nucl Med 20:1142–1149
McCarthy ID, Hughes SPF, Orr JS (1980) An experimental model to study the relationship between blood flow and uptake of bone-seeking radionuclides in normal bone. Clin Phys Physiol Meas 1:135–143
Davies DR, Bassingthwaighte JB, Kelly PJ (1976) Transcapillary exchange of strontium and sucrose in canine tibia. J Appl Physiol 40:17
Hughes SPF, Davies DR, Bassingthwaighte JB, Knox FG, Kelly PJ (1977) Bone extraction and blood clearance of diphosphonate in the dog. Am J Physiol 232:H.341
Kety SS (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3:1–40
Renkin EM (1955) Effects of blood flow on diffusion kinetics in isolated perfused hind-legs of cats. Am J Physiol 183:125–136
Renkin EM (1959) Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol 197:1205–1210
Crone C (1963) The permeability of capillaries in various organs as determined by the indicator diffusion method. Acta Physiol Scand 58:292–305
Hughes SPF, Lemon GJ, Davies DR, Bassingthwaighte JB, Kelly PJ (1979) Extraction of minerals after experimental fractures of the tibia in dogs. J Bone Joint Surg [Br] 61A:857–866
Sagar VV, Piccone JM, Charkes ND (1979) Studies of skeletal tracer kinetics:3.99mTc-MDP uptake in the canine tibia as a function of blood flow. J Nucl Med 20:1257–1261
Wootton R (1974) The single passage extraction of fluorine-18 in rabbit bone. Clin Soc Mol Med 47:73–77
Charkes ND, Brookes M, Makler PT (1979) Studies of skeletal tracer kinetics:2. Evaluation of a five compartment model of fluorine kinetics in rats. J Nucl Med 20:1150–1157
Schoutens A, Bergman P, Verhas M (1979) Bone blood flow measured by strontium-85 microspheres and bone seeker clearances in the rat. Am J Physiol 236:H1-H6
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McCarthy, I.D., Hughes, S.P.F. The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate. Calcif Tissue Int 35, 508–511 (1983). https://doi.org/10.1007/BF02405085
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DOI: https://doi.org/10.1007/BF02405085