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Esterase-16 (ES-16) of the rat (Rattus norvegicus): Identification and genetic characterization

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Abstract

Esterase-16, an esterase present in lung and other tissues of the laboratory rat, has been characterized by its biochemical properties (electrophoretic mobility, substrate pattern, sensitivity to inhibitors) and genetic variation in 107 inbred strains and substrains including 14 RI strains. It was classified as a carboxylesterase (EC 3.1.1.1). The phenotype ES-16A (BN/Han and 63 other strains) was defined as a narrow electrophoretic band migrating between ES-1A and ES-13A, ES-16B (LEW/Han and 42 other strains) exhibited the same electrophoretic mobility as ES-16A but was distinguished by its extremely weak activity. Segregation of ES-16 in RI strains and backcrosses indicated linkage to linkage group V (LGV). TheEs-16 locus was tentatively placed into esterase cluster 2 and homology withEs-7 of the house mouse is proposed.

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References

  • Bender, K., Adams, M., Baverstock, P. R., den Bieman, M., Bissbort, S., Brdicka, R., Butcher, G. W., Cramer, D. V., von Deimling, O., Festing, M. F. W., Günther, E., Guttmann, R. D., Hedrich, H. J., Kendall, P. B., Kluge, R., Moutier, R., Simon, B., Womack, J. E., Yamada, J., and van Zutphen, B. (1984). Biochemical markers in inbred strains of the rat (Rattus norvegicus).Immunogenetics 19257.

    Article  CAS  PubMed  Google Scholar 

  • Gomori, G. (1952). Histochemistry of esterase.Int. Rev. Cytol. 1323.

    Article  Google Scholar 

  • Hedrich, H. J., and von Deimling, O. (1987). Re-evaluation of linkage group V of the rat and assignment of twelve carboxylesterases to two gene clusters.J. Hered. 7892.

    CAS  PubMed  Google Scholar 

  • Hedrich, H., von Deimling, O., and Kluge, R. (1987). Biochemical genetics of Es-14 (formerly Es-Si) and a new esterase variation, Es-15, of the laboratory rat (Rattus norvegicus). Biochemistry, tissue expression, and linkage to Es-1 in linkage group V.Biochem. Genet. 2579.

    Article  CAS  PubMed  Google Scholar 

  • Holt, S. J. (1958). Indigogenic staining methods for esterases. In Danielli, J. F. (ed.),General Cytochemical Methods Academic Press, New York, Vol. 1, pp. 375–398.

    Google Scholar 

  • Hopkinson, D. A., Mestriner, M. A., Cortner, J., and Harris, H. (1973). Esterase D. A new human polymorphism.Ann. Hum. Genet. Lond. 37119.

    CAS  Google Scholar 

  • Lipps, A., Ronai, A., and von Deimling, O. (1979). Esterase-7, a common constituent of numerous mouse tissues.Comp. Biochem. Physiol. 42B201.

    Google Scholar 

  • Lundin, L.-G. (1979). Evolutionary conservation of large chromosomal segments reflected in mammalian gene maps.Clin. Genet. 1672.

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto, K. (1980). New polymorphisms of esterase-7 and esterase-8 in inbred strains of rats: Tissue expression and linkage studies.Biochem. Genet. 18879.

    Article  CAS  PubMed  Google Scholar 

  • Maurer, H. R. (1971).Disc Electrophoresis and Related Techniques of Polyacrylamide Gel Electrophoresis De Gruyter, New York.

    Google Scholar 

  • Mentlein, R., Ronai, A., Robbi, M., Heymann, E., and von Deimling, O. (1987). Genetic identification of rat liver carboxylesterases isolated in different laboratories.Biochim. Biophys. Acta 91327.

    CAS  PubMed  Google Scholar 

  • Moutier, R., Toyama, K., and Charrier, M.-F. (1973). Evidence for linkage between four esterase loci in the rat (Rattus norvegicus).Biochem. Genet. 9109.

    Article  CAS  PubMed  Google Scholar 

  • Simon, B., deLooze, S., Ronai, A., and von Deimling, O. (1985). Identification of rat liver carboxylesterase isozymes (EC 3.1.1.1) using polyacrylamide gel electrophoresis and isoelectric focusing.Electrophoresis 6575.

    Article  CAS  Google Scholar 

  • van Zutphen, L. F. M. (1983). Revision of the genetic nomenclature of esterase loci in the rat (Rattus norvegicus).Transplant. Proc. 151687.

    Google Scholar 

  • von Deimling, O., Simon, B., Kluge, R., and Hedrich, H. (1985). Private communication.Rat News Lett. 1511.

    Google Scholar 

  • Womack, J. E., and Sharp, M. (1976). Comparative autosomal linkage in mammals: Genetics of esterases in Mus musculus and Rattus norvegicus.Genetics 82665.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pathologisches Institut der Universität Freiburg, D-7800, Freiburg, F.R.G.

    Otto H. von Deimling & Babette Simon

  2. Zentralinstitut für Versuchstierzucht, Hannover, F.R.G.

    Reinhard Kluge & Hans Hedrich

Authors
  1. Otto H. von Deimling
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  2. Babette Simon
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  3. Reinhard Kluge
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  4. Hans Hedrich
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Additional information

This work was supported by the Deutsche Forschungsgemeinschaft (De 315/2). This communication No. 63 of a research program devoted to the cellular distribution, regulation, and genetics of nonspecific esterases.

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von Deimling, O.H., Simon, B., Kluge, R. et al. Esterase-16 (ES-16) of the rat (Rattus norvegicus): Identification and genetic characterization. Biochem Genet 26, 605–615 (1988). https://doi.org/10.1007/BF02399605

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  • DOI: https://doi.org/10.1007/BF02399605

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