The association between the antineoplastic drug daunomycin and iron. evidence for polynuclear aggregates
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In contrast to literature data, at millimolar iron and daunomycin (DN) concentrations no solitary Fe(DN)3 complexes are formed in appreciable amounts. The Mössbauer spectroscopic analysis revealed severe dependencies on temperature and on the metal ligand ratio. Two species can be discerned: exchange-coupled polynuclear aggregates, which are magnetically highly anisotropic and another superparamagnetic system, exhibiting much less magnetic anisotropy. The cooperative phenomena observed are attributed to stacking effects of daunomycin.
KeywordsIron Spectroscopic Analysis Thin Film Anisotropy Magnetic Anisotropy
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