Abstract
The structural characterization of a third type of α chain, detected in the hemoglobin of sheep also possessing the αLeu and theIIαHis chains, is reported. The new α-chain variant is an allele of the common αLeu chain controlled by the1α locus and differs from it in the replacement of the serine residue at position 8 with an alanine (Iα8 Ser→Ala). The alanine variant was observed in 38 of 206 sheep, whose hemolysates were analyzed by isoelectric focusing, and was found exclusively among the 57 animals also possessing theIIαHis chain.
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This research was supported in part by funds from the Italian CNR (Grant 01859.04) and from the Ministero Pubblica Istruzione.
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Vestri, R., Giordano, P.C. & Bernini, L.F. Duplication of the hemoglobin α-chain gene in sheep: Characterization of a new α-chain variant present in animals possessing the αLeu and theIIαHis chains. Biochem Genet 21, 25–35 (1983). https://doi.org/10.1007/BF02395389
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DOI: https://doi.org/10.1007/BF02395389