Summary
The disintegration of rat ascites hepatoma island (AH 601) by Tween 80 treatment was markedly enhanced, when nitrogen mustard N-oxide over the minimal effective dosis was previously contacted in vivo. The degree of the disintegration was roughly in inverse relation with the dosis of HN 2-O administrated in the present experimental condition.
In consequence, one of the important factors responsible for the inhibitory effect of HN2−O on metastasis of the rat ascites hepatoma may be an increase in the mutual adhesiveness. The interrelation between the mutual adhesiveness and the emigratory property of rat hepatoma cells was discussed.
Zusammenfassung
Die Auflösung von Asciteshepatominseln (AH 601) durch Behandlung mit Tween 80 wurde wesentlich gestört, wenn Stickstoff-Lost-Oxyd (HN2−O) in einer die minimale wirksame Dosis überschreitenden Menge mit ihnen in Berührung kam. Das Ausmaß dieser Auflösung stand unter den hier gegebenen experimentellen Bedingungen etwa im umgekehrten Verhältnis zu der angewandten Dosis von Stickstoff-Lost. Einer von den wichtigen Faktoren, die für den Hemmeffekt von HN2−O auf die Entstehung von Metastasen des Ratten-Asciteshepatoms verantwortlich sind, dürfte daher die Erhöhung des gegenseitigen Zusammenhanges der Tumorzellen sein. Auf die Beziehungen zwischen gegenseitigem Zusammenhang und der Fähigkeit zur Emigration der Ratten-Hepatomzellen wird hingewiesen.
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Yamada, T., Satou, H. Mutual adhesiveness of tumor cells in “hepatoma island” of the rat ascites hepatoma. III. The influence of nitrogen mustard N-oxide. Z Krebs-forsch 66, 109–114 (1964). https://doi.org/10.1007/BF02395335
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DOI: https://doi.org/10.1007/BF02395335