European Journal of Clinical Pharmacology

, Volume 27, Issue 1, pp 13–17 | Cite as

Long acting nifedipine in the treatment of severe hypertension

  • M. Bursztyn
  • E. Grossmann
  • T. Rosenthal


The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.

Key words

nifedipine hypertension blood pressure decrease drug combination 


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  1. 1.
    Braunwald E (1982) Mechanism of action of calcium-channel-blocking agents. N Engl J Med 307: 1618–1627PubMedGoogle Scholar
  2. 2.
    Stone PH, Antman EM, Muller JE, Braunwald E (1980) Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. Ann Int Med 93: 886–904PubMedGoogle Scholar
  3. 3.
    Antman E, Muller J, Goldberg S, MacAlpin R, Rubenfire M, Tabatznik B. Liang C, Heupler F, Achuff S, Reichek N, Geltman E, Kerin NZ, Niff RK, Braunwald E (1980) Nifedipine therapy for coronary artery spasm experience in 127 patients. N Engl J Med 302: 1269–73PubMedGoogle Scholar
  4. 4.
    Moses JW, Wertheimer JH, Bodenheimer MA, Banka VS, Feldman M (1981) Efficacy of nifedipine in rest angina refractory to propranolol and nitrates in patients with obstructive coronary artery disease. Ann Int Med 94: 425–429PubMedGoogle Scholar
  5. 5.
    Corvol P, Marre M, Banzet O, Colin JN, Thibonnier M, Singlas E, Alexandre JM (1983) Acute antihypertensive effects and pharmacokinetic parameters of a new galenic form of nifedipine in the 5th International Adalat Symposium. Kaltenbach M, Neufeld HN (eds). Excerpta MedicaGoogle Scholar
  6. 6.
    Haber E, Koerner T, Page LB, Kliman B, Purnode A (1969) Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab 29: 1349–1355PubMedGoogle Scholar
  7. 7.
    Buhler FR, Sealey JE, Laragh JH (1974) Radioimmunoassay of plasma aldosterone. In: Laragh JH (ed) Hypertension manual York Medical Books, New York, p 655Google Scholar
  8. 8.
    Brunner HR, Sealey JE, Laragh JH (1974) Renin as a risk factor in essential hypertension: more evidence. In: Laragh JH (ed) Hypertension manual York Medical Books, New York, pp 71–75Google Scholar
  9. 9.
    Ueda K, Murakami M (1983) A controlled, comparative multicenter study on the clinical efficacy of nifedipine in the treatment of severe hypertension in the 5th International Adalat Symposium Kaltenbach M, Neufeld HN (eds). Excerpta Medica pp 146–155Google Scholar
  10. 10.
    Mueller HS, Chahine RA (1981) Interim report of multicenter double-blind, placebo-controlled studies of nifedipine in chronic stable angina. Am J Med 71: 645–657CrossRefPubMedGoogle Scholar
  11. 11.
    Olivari MT, Bartorelli C, Polese A, Fiorentini C, Moruzzi P, Guazzi D (1979) Treatment of hypertension with nifedipine, a calcium antagonist agent circulation 59: 1056–1062Google Scholar
  12. 12.
    Hedland A, Heidbreder E, Horl WH, Schafer R (1982) Calcium antagonists in the treatment of hypertension Contrib Nephrol 33: 254–269Google Scholar
  13. 13.
    Hill JA, Feldman RL, Pepine CJ, Conti CR (1982) Randomized double-blind comparison of nifedipine and coronary arterial spasm. Am J Cardiol 49: 431–438CrossRefPubMedGoogle Scholar
  14. 14.
    Lynch P, Dargie H, Krikler S, Krikler D (1980) Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination. Br Med J 280: 184–187Google Scholar
  15. 15.
    Millar JA, Reid JL (1983) Decreased vascular and adrenal responses to angiotensin II after administration of nifedipine in the 5th International Adalat Symposium. Kaltenbach M, Neufeld HN (eds). Excerpta Medica, pp 122–129Google Scholar
  16. 16.
    Hiramatsu K, Yamagishi F, Kubota T, Yamada T (1982) Acute effects of the calcium antagonist, nifedipine, on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension. Am Heart J 104: 1346CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. Bursztyn
    • 1
  • E. Grossmann
    • 1
  • T. Rosenthal
    • 1
  1. 1.Department of Medicine D, Hypertension UnitTel-Aviv University Medical School, The Chaim Sheba Medical CenterTel HashomerIsrael

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