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Hyperlipidemia and pancreatitis

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Abstract

A total of 117 patients with pancreatitis were studied during the acute attack and after remission, and 32.5% were found to have hyperlipidemia, nearly all of type IV. There did not seem to be a relationship between hyperlipidemia and alcohol intake, although nearly 80% of the patients were alcoholics. No defect in triglyceride turnover could be demonstrated by intravenous fat tolerance tests or postheparin lipolytic activity measurements. No correlation was found between hyperlipidemia and steatosis of the liver or diabetes.

It is suggested that the increase in serum triglyceride levels might be due to an increased synthesis or mobilization. It is also suggested that the hypertriglyceridemia does not directly induce an attack of pancreatitis, but might predispose a patient to develop pancreatitis when other provoking factors are also present.

Résumé

Cent dix-sept malades atteints de pancréatite aiguë ont été étudiés, soit pendant la crise, soit pendant les périodes de rémission. Une hyperlipidémie a été trouvée dans 32.5% des cas, presque toujours de type IV. Bien que 80% des malades soient des alcooliques, l'hyperlipidémie parait être sans relation avec l'alcoolisme. Le test de tolérance à l'administration i.v. de graisse et la mesure de l'activité lipolytique après administration d'héparine n'ont pas montré d'altération du turnover des triglycérides, mais uniquement une réduction modérée de la fraction hépatique de l'activité lipolytique. Nous n'avons observé aucune corrélation entre hyperlipidémie, stéatose hépatique et diabète.

L'élévation des triglycérides plasmatiques peut être due soit à une synthèse augmentée, soit à une libération accrue des dépôts périphériques. Nous avons l'impression que l'hypertriglycéridémie n'est pas directement responsable de la crise de pancréatite; elle peut être un élément prédisposant lorsqu'elle est associée à d'autres facteurs déclenchants.

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Authors and Affiliations

  1. Kommunehospitalet, Department 1, Diakonissestiftelsen, Medical Department C, Copenhagen, Denmark

    Annette Buch M.D., Jan Buch M.D., Agnete Carlsen M.D. & Arne Schmidt M.D.

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  1. Annette Buch M.D.
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  2. Jan Buch M.D.
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  3. Agnete Carlsen M.D.
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Buch, A., Buch, J., Carlsen, A. et al. Hyperlipidemia and pancreatitis. World J. Surg. 4, 307–312 (1980). https://doi.org/10.1007/BF02393387

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