Skip to main content

Advertisement

SpringerLink
Log in

The proper use of local antimicrobial agents in wounds

  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Topical antibiotics have been shown to be effective prophylactic agents in reducing wound infection in clean and clean-contaminated cases. The risk of the development of superinfection and antibiotic resistant bacteria, as well as organ toxicity, is minimal as compared to the use of systemic antibiotics in clean operations. The combination of systemic and topical chemotherapeutic drugs is a valuable adjunct in the treatment of contaminated wounds and high risk patients.

Résumé

Il a été démontré que les antibiotiques in loco réalisent une prophylaxie efficace, réduisant la fréquence des infections de plaie dans les opérations propres et contaminées. Les resques de développement d’une surinfection, de résistance aux antibiotiques et de toxicité sont, dans les opérations propres, de loin inférieurs aux risques de l’antibiothérapie par voie générale. Dans le traitement des plaies contaminées et chez les malades à haut risque, l’association d’antibiotiques par voies locale et générale est utile.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Moylan, J.A., Balish, E., Chan, J.: Intraoperative bacterial transmission. Surg. Gynecol. Obstet.141:731, 1975

    CAS  PubMed  Google Scholar 

  2. Dubuc, F., Guimont, A., Roy, L., Ferland, J.J.: A study of some factors which contribute to surgical wound contamination. Clin. Orthop.96:176, 1973

    PubMed  Google Scholar 

  3. Porter, K.W.: Environmental sanitation surgical suite. Hospitals46:October, 1972

  4. Chodak, G.W., Plaut, M.E.: Use of systemic antibiotics for prophylaxis in surgery. Arch. Surg.112:326, 1977

    CAS  PubMed  Google Scholar 

  5. Bennett, J., Scheckler, W., Maki, O.: Current patterns of nosocomial infections in the United States. Proceedings of the International Conference on Nosocomial Infection, 1971

  6. Johanson, W., Pierce, A., Sanford, J.: Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Ann. Intern. Med.77:701, 1972

    PubMed  Google Scholar 

  7. Rose, H., Babcock, J.: Colonization of intensive care unit patients with gram-negative bacilli. Am. J. Epidemiol.101:495, 1975

    CAS  PubMed  Google Scholar 

  8. Glotzer, D.J., Goodman, W.S., Geronimus, L.H.: Prevention by topical antibiotics of experimental wound infections produced by enteric bacteria. Surg. Forum20:54, 1969

    CAS  PubMed  Google Scholar 

  9. Casten, D.F., Nach, R.J., Spinzia, J.: An experimental and clinical study of the effectiveness of antibiotic wound irrigation in preventing infection. Surg. Gynecol. Obstet.118:783, 1964

    CAS  PubMed  Google Scholar 

  10. Spier, R.: Prevention of experimental staphylococcus wound infection in rabbits with topical kanamycin. Surgery55:421, 1964

    CAS  PubMed  Google Scholar 

  11. Brockenbrough, E.C., Moylan, J.A.: Treatment of contaminated surgical wound with topical antibiotics. Am. Surg.35:789, 1969

    CAS  PubMed  Google Scholar 

  12. Rickett, J.W.S., Jackson, B.T.: Topical ampicillin in the appendectomy wound. Br. Med. J.4:206, 1969

    Article  CAS  PubMed  Google Scholar 

  13. Mountain, J.C., Seal, P.V.: Topical ampicillin in gridiron appendectomy wounds. Br. J. Clin. Pract.24:111, 1970

    CAS  PubMed  Google Scholar 

  14. Lord, J.W., Rossi, G., Daliana, M.: Intraoperative antibiotic wound lavage: an attempt to eliminate postoperative infection in arterial and clean general surgical procedures. Ann. Surg.185:634, 1977

    CAS  PubMed  Google Scholar 

  15. Andersen, B., Korner, B., Ostergaard, A.H.: Topical ampicillin against wound infection after colorectal surgery. Ann. Surg.176:129, 1972

    CAS  PubMed  Google Scholar 

  16. Polk, H.C., Lopez-Mayor, J.F.: Postoperative wound infections: a prospective study of determinant factors and prevention. Surgery66:97, 1969

    PubMed  Google Scholar 

  17. Bryant, L.R., Dillon, M.D., Mobin-Uddin, K.: Prophylactic antibiotics in noncardiac thoracic operations. Ann. Thorac. Surg.19:670, 1975

    Article  CAS  PubMed  Google Scholar 

  18. Matolo, N.M., Cohen, S.E., Wolfman, E.F.: Effects of antibiotics on prevention of infection in contaminated abdominal operations. Am. Surg.42:123, 1976

    CAS  PubMed  Google Scholar 

  19. Eftekhar, N.S., Bush, D.C., Freeman, A.R., Stinchfield, F.E.: Perioperative management of total hip replacement. Orthopaedic Review3:17, 1974

    Google Scholar 

  20. Belzer, F.O., Salvatierra, O. Schweizer, R.T., Kountz, S.L.: Prevention of wound infections by topical antibiotics in high risk patients. Am. J. Surg.126:180, 1973

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Joseph A. Moylan M.D.

Authors
  1. Joseph A. Moylan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moylan, J.A. The proper use of local antimicrobial agents in wounds. World J. Surg. 4, 433–437 (1980). https://doi.org/10.1007/BF02393169

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02393169

Keywords

Search

Navigation