Primary Fallopian tube carcinoma — a retrospective survey of 51 cases
- 25 Downloads
Objective: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I).Design: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were devided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation).Results: Patients of stage 0 had a significantly better prognosis than patients of stage I (p=0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p=0.017).Conclusion: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
Key wordsFallopian tube carcinoma Stage 0 Stage I Chemotherapy Irradiation
Unable to display preview. Download preview PDF.
- Frick II HC (1978) Cancer of the Fallopian tube. In: Gusberg SB, Frick HC (eds) Corscadens Gynecol Cancer 5th edn. Williams & Wilkins, Baltimore, pp 368–374Google Scholar
- Kone M, Body G, Calais G, Fignon A, Fetissof F, Lansac J (1992) Adenocarcinoma primitif de la trompe. J Gynecol Obstet Biol Reprod 21: 187–192Google Scholar
- Pakisch B, Poschauko J, Stücklschweiger G, Poier E, Lahousen M, Pickel H et al. (1990) Die Behandlung des primären Karzinoms der Tuba Fallopii. Geburth Frauenheilk 50: 593–596Google Scholar
- Phelps HM Chapman KE (1973) Role of radiation therapy in treatment of primary carcinoma of the uterine tube. Obstet Gynecol 43: 669–673Google Scholar
- Schray MF, Podratz KC, Malkasian GD (1987) Fallopian tube cancer: The role of radiation therapy. Radiotherapy Oncol 10: 267–275Google Scholar
- Tamini HK, Figge DC (1981) Adenocarcinoma of the uterine tube: potential for lymph node metastasis. Am J Obstet Gynecol 141: 132–137Google Scholar