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Pulsatile versus continuous oxytocin infusion for the oxytocin challenge test

Abstract

In a prospective study, 140 patients had an oxytocin challenge test with either a continuous or a pulsed infusion (one minute of infusion in every five minutes). Both infusion regimens had similar success rates in terms of uterine contractions (97.1 vs 98.6%). The potency ratio (pulsed versus continuous infusion) was significant at 2.7 (1.27 to 5.2), which means that more uterine activity was induced with each mU of oxytocin with pulsatile than with continuous administration. The total amount of oxytocin required to obtain three good contractions in 10 minutes was about 40% less with pulsed administration than with continuous infusion, but the test took 40 minutes longer with the pulsed than with the continuous infusion (P<0.01).

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References

  • American Society of Hospital Pharmacy (1993) Oxytocin. In: American Hospital Formulary Service. Bethesda, pp 2039–2041

  • Chard T, Gibbens GLD (1983) Spurt release of oxytocin during surgical induction of labor in women. Am J Obstet Gynecol 147:467–680

    Google Scholar 

  • Cummiskey KC, Dawood Y (1990) Induction of labor with pulsatile oxytocin. Am J Obstet Gynecol 163:1868–1874

    CAS  PubMed  Google Scholar 

  • Dawood MY, Ylikorkala O, Trivedi D, Fuchs F (1979) Oxytocin in maternal circulation and amniotic fluid during pregnancy. J Clin Endocrinol Metab 49:429–434

    CAS  PubMed  Article  Google Scholar 

  • Freeman RK, Garite TJ (1981) Antepartum fetal monitoring. In: Freeman RK, Garite TJ (eds) Fetal heart rate monitoring. 1st Edition. Williams and Wilkins, Baltimore, pp 113–129

    Google Scholar 

  • Fuchs AR, Romero R, Keefe D, Parra M, Oyarzum E, Behnke E (1991) Oxytocin secretion and human parturition: Pulse frequency and duration increase during spontaneous labor in women. Am J Obstet Gynecol 165:1515–1523

    CAS  PubMed  Google Scholar 

  • Gonzalez-Panizza VH, Sica-Blanco Y, Mendez-Bauer C (1961) The fate of injected oxytocin in the pregnant women near term. In: Caldeyro-Barcia R, Heller H (eds) Oxytocin. Pergamon Press, New York, pp 347–357

    Google Scholar 

  • Odem RR, Work BA, Dawood Y (1988) Pulsatile oxytocin for induction of labor: a randomized prospective controlled study. J Perinatol Med 16:31–37

    CAS  Article  Google Scholar 

  • Pavlou C, Barker GH, Roberts A, Chamberlain GVP (1978) Pulsed Oxytocin infusion in the induction of labour. Br J Obstet Gynaecol 85:96–100

    CAS  PubMed  Google Scholar 

  • Randolph GW, Fuchs AR (1989) Pulsatile administration enhances the effect and reduces the dose of oxytocin required for induction of labor. Am J Perinat 6:159–166

    CAS  Article  Google Scholar 

  • Ryden G, Sjoholm I (1971) The metabolism of oxytocin in pregnant and nonpregnant women. Acta Obstet Gynecol Scand 50:37–41

    Article  Google Scholar 

  • Sica-Blanco Y, Sala NL (1961) Uterine contractility at the beginning and end of an oxytocin infusion. In: Caldeyro-Barcia R, Heller H (eds) Oxytocin. Pergamon Press, New York, pp 127–136

    Google Scholar 

  • Steichik JS, Amico J, Robinson AG, Castillo M (1984) Oxytocin augmentation of dysfunctional labor. IV. Oxytocin Pharmacokinetics. Am J Obstet Gynecol 150:225–228

    Google Scholar 

  • Tallarida RJ, Murray RB (1987) Manual of pharmacologic calculations with computer programs. 2nd Edition. Springer-Verlag, New York

    Google Scholar 

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Perales, A.J., Diago, V.J., Monleón-Sancho, J. et al. Pulsatile versus continuous oxytocin infusion for the oxytocin challenge test. Arch Gynecol Obstet 255, 119 (1994). https://doi.org/10.1007/BF02390938

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  • DOI: https://doi.org/10.1007/BF02390938

Key words

  • Oxytocin challenge test
  • Fetal well being
  • Oxytocin