Abstract
Objective: To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival.Design: A nationwide retrospective analysis.Setting: Hanusch-Krankenhaus, Department of Gynaecology.Subjects: 115 patients with histologically proved primary carcinoma of the Fallopian tube: 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment.Results: The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P=0.62).Conclusions: Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
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In cooperation with: C. Altmutter, G. Bartussek, M. Bayr, A. Bichler, L. Fuith, W. Grünberger, K. Kahn, S. Karasegh, H. Krahuletz, L. Leodeolter, M. Medl, H. Salzer, A. Schröck, M. Stiglbauer, S. Szalay, R. Taschner, A. Wellenhofer, N. Wirrani, G. Wolfram
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Klein, M., Rosen, A., Lahousen, M. et al. Evaluation of adjuvant therapy after surgery for primary carcinoma of the Fallopian tube. Arch Gynecol Obstet 255, 19–24 (1994). https://doi.org/10.1007/BF02390670
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DOI: https://doi.org/10.1007/BF02390670