Radiologic anthropometry of the hand in patients with familial short stature
- 33 Downloads
Fifth metacarpal bone shortening (brachymetacarpia V) was recently described to be highly prevalent in children with familial short stature (FSS). To characterize the hand bones of FSS patients with and without brachymetacarpia V, the left hand bone age radiographs of 26 FSS children were reviewed. In 16/19 patients with clinical brachymetacarpia V radiographs revealed fifth metacarpal bone shortening with a gap of 2 mm or more between the distal end of the fifth metacarpal bone and a tangential line connecting the distal ends of the third and fourth metacarpal bones. Only one of 7 patients without clinical brachymetacarpia V had a gap of 2 mm. Radiologic anthropometry revealed that FSS patients with clinically shortened fifth metacarpal bone frequently had shortened first metacarpal bones, second and third proximal phalanges, and fifth distal phalanx as well. FSS patients without clinical fifth metacarpal bone shortening had shortened third and fourth metacarpal bones, fifth proximal phalanx, and fifth distal phalanx. Fifth metacarpal bone shortening was only detected clinically if the fourth metacarpal bone was not short as well. Reduction in height correlated more with reduction in metacarpal bone length than with that of the other hand bones. These peculiar tubular bone alterations commonly seen in FSS suggest a disturbance in endochondral ossification, the process primarily involved in tubular bone elongation.
KeywordsPublic Health Short Stature Tangential Line Endochondral Ossification Proximal Phalanx
Unable to display preview. Download preview PDF.
- 1.Van der Werff Ten Bosch JJ (1959) The syndrome of brachymetacarpal dwarfism (Pseudo-pseudohypoparathyroidism) with and without gonadal dysgenesis. Lancet 1 (7086): 69Google Scholar
- 2.Bell J (1951) Brachydactyly and symphalangism. In: Penrose LS (ed) Treasury of human inheritance. Cambridge University Press, London p 1Google Scholar
- 3.Temtamy S, McKusick V (1978) The genetics of hand malformations: Birth defects. Alan R Liss, New York p 187Google Scholar
- 4.Drinkwater H (1975) Account of a family showing minor brachydactyly. J Genetics 2: 21Google Scholar
- 5.Cervantes C, Lifshitz F (1986) Tubular bone alterations in familial short stature patients (Abstract). J Bone Min Res 1 [Suppl 1]: 201Google Scholar
- 6.Cervantes C, Lifshitz F (1988) Tubular bone alterations in familial short stature. Human Biology (in press)Google Scholar
- 9.Kosowicz J (1965) The roentgen appearance of the hand and wrist in gonadal dysgenesis. AJR 93: 354Google Scholar
- 11.Poznanski AK (1974) The hand in radiologic diagnosis. Saunders, Philadelphia p 29Google Scholar
- 13.Lifshitz F, Zandsberg S (1985) Disorders of growth. In: Lifshitz F (ed) Pediatric endocrinology. Marcel Dekker, New York p 14Google Scholar