Summary
Maternal serum estradiol and progesterone levels during the early 6th to 15th weeks of gestation, were measured by radioimmunoassay in 140 pregnancies following induction of ovulation with gonadotropins or clomiphene citrate. The levels were compared with those observed in 79 spontaneous pregnancies. Significantly higher levels were observed in gonadotropin and clomiphene citrate induced pregnancies (bothP values <0.001) between the 6th to 9th week of gestation as compared to spontaneous pregnancies. Steroid levels were similar in the two groups from the 9th week onwards. No statistically significant differences in steroid hormone values were observed in aborted and successful pregnancies within each group studied. We conclude that ovulation induction is associated with higher estradiol and progesterone levels until placental steroidogenesis starts.
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Abraham GE, Hopper K, Tulchinsky D, Swerdloff RS, Odell WD (1971) Simultaneous measurement of plasma progesterone, 17-hydroxyprogesterone and estradiol-17B by radioimmunoassay. Anal Lett 4:325–335
Aspillaga MO, Whittaker PG, Grey CE, Lind T (1983) Endocrinologic events in early pregnancy failure. Am J Obstet Gynecol 147:903–908
Batzer FR (1980) Hormonal evaluation of early pregnancy. Fertil Steril 34:1–13
Bergquist C, Nillius SJ, Wide L (1983) Human gonadotropin therapy. I. Serum estradiol and progesterone patterns during conceptual cycles. Fertil Steril 39:761–765
Garcia J, Jones GS, Acosta AA, Wright GL Jr (1981) Corpus luteum function after follicle aspiration for oocyte retrieval. Fertil Steril 36:565–572
Johansson DB (1969) Plasma levels of progesterone in pregnancy measured by a rapid competitive protein binding technique. Acta Endocrinol 61:607–617
Jones GS, de Moraes-Ruehsen MD (1967) Clomiphene citrate for improvement of ovarian function. Am J Obstet Gynecol 99:814–828
Karow WG, Gentry WC (1976) Corpus luteum function during pregnancies of previously infertile women. Obstet Gynecol 48:603–610
Mishell DR, Thorneycroft IH, Nagata Y, Murata T, Nakamura RM (1973) Serum gonadotropin and steroid patterns early human gestation. Am J Obstet Gynecol 117:631–642
Radwanska E (1974) Plasma progesterone estimation in infertile women and in women under treatment with clomiphene and chorionic gonadotrophin. J Obstet Gynaecol Br Commonw 81:107–112
Radwanska E, Maclin V, Rana N, Henig I, Rawlins R, Dmowski PW (1988) Early endocrine events in induced pregnancies. Int J Fertil 33:162–167
Robertson DM, Mester J, Kellie AE (1971) The measurement of oestradiol and progesterone in plasma from normal, infertile and clomiphene treated women. Acta Endocr 68:523–533
Schweditsch MO, Dubin NH, Jones GS, Wentz AC (1979) Hormonal consideration in early normal pregnancy and blighted ovum syndrome. Fertil Steril 31:252–257
Strigini F, Collins WP, Whitehead MI, Melis GB, Fioretti P, Campbell S (1986) Hormone excretion during early pregnancy following spontaneous and clomiphene citrate-induced ovulation. Fertil Steril 46:209–214
Tsapoulis AD, Zourlas PA, Comninos AC (1979) Observation on 320 infertile patients treated with human gonadotropins (human menopausal gonadotropin/human chorionic gonadotropin) Fertil Steril 29:492–495
Tulchinsky D, Hobel CJ (1973) Plasma human chorionic gonadotropin, estrone, estradiol, estriol, progesterone, and 17-a hydroxyprogesterone in human pregnancy. III. Early normal pregnancy. Am J Obstet Gynecol 117:884–893
Tulchinsky D, Okada DM (1975) Hormones in human pregnancy. IV. Plasma progesterone. Am J Obstet Gynecol 121:293–299
Whittaker PG, Stewart MO, Taylor A, Lind T (1989) Some endocrinological events associated with early pregnancy failure. Br J Obstet Gynaecol 96:1207–1214
Willcox DL, Yovich JL, McColm SC, Schmitt LH (1985) Changes in total and free concentrations of steroid hormones in the plasma of women throughout pregnancy: effects of medroxyprogesterone acetate in the first trimester. J Endocrinol 107:293–300
Yoshimi T, Strott CA, Marshall JR, Lipsett MB (1969) Corpus luteum function in early pregnancy. J Clin Endocrinol 29:225–230
Yovich JL, Stanger JD, Yovich JM, Tuvik AI, Turner SR (1985) Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies arising from in-vitro fertilization. Br J Obstet Gynaecol 92:374–384
Yovich JL, Willcox DL, Grudzinskas JG, Bolton AE (1986) The prognostic value of hCG, PAPP-A, oestradiol-17B and progesterone in early human pregnancy. Aust NZ J Obstet Gynaecol 26:59–64
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Hassiakos, D., Mantzavinos, T., Kalomiris, K. et al. Comparison of maternal serum estradiol and progesterone levels in pregnancies after induced and spontaneous ovulation. Arch Gynecol Obstet 248, 145–150 (1991). https://doi.org/10.1007/BF02390092
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DOI: https://doi.org/10.1007/BF02390092