Medical Microbiology and Immunology

, Volume 177, Issue 6, pp 333–338 | Cite as

Rapid detection of pneumococcal antigens in sputa in patients with community-acquired pneumonia by coagglutination

  • Zhang Xiaoping 
  • Deng Kuen 
  • Ye Yaoqing 
  • Luo Wentong 


This paper introduces the clinical use of coagglutination as a method for the rapid detection of pneumococcal antigens in patients with community-acquired pneumonia and compares it with the sputum Gram stain and culture methods. Among 105 patients, 50 (48%) were diagnosed as having pneumococcal pneumonia by at least one of the three methods. Of 95 sputa tested, 44 (46%) were found to be positive by the coaggulation test, 26 (27%) by Gram staining and only 16 (17%) by the bacterial culture method. The rate of detection of pneumococcal antigens was thus greater with coaggulation than with either of the other two methods. The differences were very significant (bothP<0.01). Our study indicates that the advantages of coagglutination over the traditional bacteriological methods are its speed, sensitivity, convenience and also its relative independence of antibiotic therapy. It thus provides a new dimension in the aetiological diagnosis of pneumococcal pneumonia.


Pneumonia Antibiotic Therapy Bacterial Culture Culture Method Rapid Detection 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Zhang Xiaoping 
    • 1
  • Deng Kuen 
    • 1
  • Ye Yaoqing 
    • 1
  • Luo Wentong 
    • 1
  1. 1.Respiratory DepartmentChangzheng Hospital. The Second Military Medical CollegeShanghaiChina

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