Archives of Gynecology and Obstetrics

, Volume 252, Issue 2, pp 81–86 | Cite as

A controlled study of maternal serum concentrations of lipoproteins in pregnancy-induced hypertension

  • H. Franz
  • D. Wendler
Originals

Summary

Seventeen women with pregnancy-induced hypertension (PIH) and 17 controls with uncomplicated pregnancy who were matched for maternal and gestational age were investigated for lipid concentrations in whole serum and lipoprotein fractions. The triglyceride level in the low-density lipoprotein fraction was higher in PIH patients than in controls (P<0.03). The differences between values of other parameters did not attain the level of statistical significance, although the tendency of the results was consistent with findings reported in other studies. The differences observed were small and the data exhibited wide variation. Therefore, it appears unlikely that serum lipid and lipoprotein concentrations could gain major clinical importance as diagnostic parameters in PIH.

Key words

Lipid(s) Lipoprotein(s) Pregnancy Pregnancy-induced hypertension 

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References

  1. 1.
    Anonymous (1974) Manual of laboratory operations. Lipid Research Clinics Program. National Heart and Lung Institute. NIH, Bethesda, Maryland 20014 (DHEW Publ No 75-628)Google Scholar
  2. 2.
    Anonymous (1990) National high blood pressure education program working group report on high blood pressure in pregnancy. Am J Obstet Gynecol 163:1691–1712Google Scholar
  3. 3.
    Austin MA (1989) Plasma triglyceride as a risk factor for coronary heart disease. Am J Epidemiol 129:249–259PubMedGoogle Scholar
  4. 4.
    Desoye G, Schweditsch MO, Pfeiffer KP, Zechner R, Kostner GM (1987) Correlation of hormones with lipid and lipoprotein levels during normal pregnancy and postpartum. J Clin Endocrinol Metab 64:704–712PubMedGoogle Scholar
  5. 5.
    Eisenberg S (1987) Lipoprotein abnormalities in hypertriglyceridemia: significance in atherosclerosis. Am Heart J 113:555–561PubMedCrossRefGoogle Scholar
  6. 6.
    Kästner P, Bepperling F, Schmahl FW (1989) Oral fat tolerance test for study of postprandial serum lipids and lipoproteins. Clin Ter Cardiovasc 8:145–148Google Scholar
  7. 7.
    Kyank H (1990) Schwangerschaftshypertonie, Präeklampsie, Eklampsie. In: Beller FK, Kyank H (eds) Erkrankungen während der Schwangerschaft, 5th edn. Thieme, Leipzig, pp 96–114Google Scholar
  8. 8.
    Maseki M, Nishigaki I, Hagihara M, Tomoda Y, Yagi K (1981) Lipid peroxide levels and lipid content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia. Clin Chim Acta 115:155–161PubMedGoogle Scholar
  9. 9.
    Meincke, Kopietz K (1986) Veränderungen des Fettstoffwechsels während der Gravidität im Zusammenhang mit Gestosen. Zentralbl Gynäkol 108:511–513PubMedGoogle Scholar
  10. 10.
    Patsch JR (1987) Postprandial lipaemia. Baillières Clin Endocrinol Metab 1:551–580PubMedGoogle Scholar
  11. 11.
    Peng HQ, Yang SZ, Zhang GY, Liang JZ, Luo ZT, Zhang XX (1985) Serum lipid and lipoprotein metabolism in toxemia of pregnancy. Chin Med J 98:905–908PubMedGoogle Scholar
  12. 12.
    Potter JM, Nestel PJ (1979) The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol 133:165–170PubMedGoogle Scholar
  13. 13.
    Rosing U, Samsioe G, Ölund A, Johansson B, Kallner A (1989) Serum levels apoliprotein A-I, A-II and HDL-cholesterol in second half of normal pregnancy and in pregnancy complicated by pre-eclampsia. Horm Metab Res 21:376–382PubMedGoogle Scholar
  14. 14.
    Schmahl FW, Prickler P, Pötter E, Tschirdewahn B, Heckers H (1983) Are fasting serum triglyceride concentrations sufficient for determining the risk factor status of hypertriglyceridaemia for atherosclerotic vascular diseases? VASA 12:353–356PubMedGoogle Scholar
  15. 15.
    Teichmann AT, Wieland H, Cremer P, Kulow G, Mehle U (1988) Serumlipid- und Lipoproteinkonzentrationen in der Schwangerschaft und zum Zeitpunkt der Geburt bei normalem sowie durch hypertensive Gestose und kindliche Mangelentwicklung kompliziertem Schwangerschaftsverlauf. Geburtshilfe Frauenheilkd 48:134–149PubMedGoogle Scholar
  16. 16.
    Yamaguchi K (1988) Triglycerides and apoproteins in toxemia of pregnancy. Acta Obst Gynaec Jpn 40:1875–1882Google Scholar
  17. 17.
    Ylöstalo P, Järvinen PA, Huhtala H (1974) Serum lipids and lipoproteins in hepatosis of pregnancy and pre-eclampsia. Ann Chir Gynaecol Fenn 63:11–13PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • H. Franz
    • 1
  • D. Wendler
    • 2
  1. 1.Department of Obstetrics and GynaecologyUniversity of TübingenTübingenFederal Republic of Germany
  2. 2.Department of Occupational and Social MedicineUniversity of TübingenTübingenFederal Republic of Germany

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