Summary
Serum gonadotropin, prolactin, estradiol, sex hormone binding globulin (SHBG) and androgen levels were measured before, 5 days and 6 weeks following ovarian wedge resection in 9 patients with polycystic ovary syndrome. Elevated levels of LH, androstenedione, testosterone and dehydroepiandrosterone-sulphate (DHEA-S) were found before surgery. There was a marked decrease in androstenedione and DHEA-S levels 5 days following wedge resection, but a rebound effect could be observed 6 weeks later. Serum gonadotropin, prolactin, testosterone and SHBG concentrations were practically unaffected by surgery. At 6–12 months follow up patients showed regular, mainly ovulatory cycles, but pregnancy occured only in two cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Adashi EJ, Rock JA, Guzick D, Wentz AC, Jones GS, Jones HW jr (1981) Fertility following bilateral ovarian wedge resection, a critical analysis of 90 consecutive cases of the polycystic ovary syndrome. Fertil Steril 36:320–325
Calogero AE, Macchi M, Montanini V, Mongioi A, Maugeri G, Vicari E, Coniglione F, Sipione C, D'Agata R (1987) Dynamics of plasma gonadotropin and sex steroid release in polycystic ovarian disease after pituitary-ovarian inhibition with an analog of gonadotropin-releasing hormone. J Clin Endocrinol Metab 64:980–985
Findley P (1904) Cystic degeneration of the ovary. Am J Obstet Dis Women Child 49:762
Gjonnaess H, Norman N (1987) Endocrine effects of ovarian electrocautery in patients with polycystic ovarian disease. Br J Obstet Gynaecol 94:779–783
Goldzieher JW (1967) Polycystic ovarian disease. In: Marcus SL, Marcus CC (eds) Advances in Obstetrics and Gynecology, vol I. Williams Wilkin, Baltimore
Goldzieher JW (1981) Polycystic ovarian disease. Fertil Steril 35:371–394
Greenblatt RB, Mahesh VB (1983) The androgenic polycystic ovary. In: Greenblatt RB, Mahesh VB (eds) Hirsutism and virilism: pathogenesis, diagnosis and treatment. Wright, Boston, p 213
Hammerstein J, Rice BF, Savard K (1964) Steroid hormone formation on the human ovary: identification of steroids formed in vitro from acetate-1-C in the corpus luteum. J Clin Endocrinol 24:597–605
Jacobs HS (1987) Polycystic ovaries and polycystic ovary syndrome. Gynecol Endocrinol 1:113–131
Judd HL, Rigg LA, Anderson DC, Yen SSC (1976) The effects of ovarian wedge resection on circulating gonadotropin and ovarian steroid levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 43:347–355
Kirschner MA, Zucker IR, Jespersen D (1976) Idiopathic hirsutism — an ovarian abnormality. N Eng J Med 294:637–640
Mahesh VB, Greenblatt RB (1964) Steroid secretions of the normal and polycystic ovary. Rec Prog Horm Res 20:341–346
McKenna TJ (1988) Pathogenesis and treatment of polycystic ovary syndrome. N Engl J Med 318:558–562
McKenna TJ, Cunningham SK, Loughlin T (1986) Ovarian estradiol secretion is suppressed and the LH/FSH ratio is elevated in the common forms of amenorrhoea. In: Genazzani AR, Volpe A, Facchinetti F (eds) Research on gynecological endocrinology. Parthenon, Carnforth, pp 157–168
Rebar R, Judd HL, Yen SSC, Rakoff J, Vandenberg G, Naftolin F (1976) Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 57:1320–1329
Stein IF, Cohen MR (1939) Surgical treatment of bilateral polycystic ovaries, amenorrhea and sterility. Am J Obstet Gynecol 38:465–470
Stein IF, Leventhal ML (1935) Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 29: 181–191
Yen SSC (1980) The polycystic ovary syndrome. Clin Endocrinol 12:177–207
Yen SSC (1986) Chronic anovulation caused by peripheral endocrine disorders. In: Yen SSC, Jaffe R (eds) Reproductive endocrinology (2nd edn). Saunders, Philadelphia, pp 441–499
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Szilágyi, A., Rossmanith, W., Csermely, T. et al. Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome. Arch Gynecol Obstet 248, 31–35 (1990). https://doi.org/10.1007/BF02389587
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02389587