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Maternal serum fructosamine and maternofetal glucose and insulin homeostasis in normal pregnancy

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Summary

Well-defined normal values are necessary to identify pregnancies complicated by gestational diabetes (GD) and thus further reduce perinatal morbidity and mortality from this condition. The present study defined the range for the oral glucose tolerance test (oGTT) in 2578 pregnancies. After exclusion of abnormal results 822 randomized patients were used to define normal values for fructosamine, HbA1c, insulin, glucose and C-peptide in the maternal serum; insulin, glucose and fructosamine in the amniotic fluid; and insulin, glucose, C-peptide and fructosamine in the cord blood.

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References

  • Artal R, Mosley GM, Dorey FJ (1984) Glycohemoglobin as a screening test for gestational diabetes. Am J Obstet Gynecol 148:412–414

    CAS  PubMed  Google Scholar 

  • Ashby JP, Frier BM (1988) Is serum fructosamine a clinical useful test? Diab Med 5:118–121

    CAS  Google Scholar 

  • Bacigalupo G, Langner K, Saling E (1984) Glycosylated hemoglobin (HbA1) glucose tolerance and neonatal outcome in gestational diabetic and non-diabetic mothers. J Perinat Med 12:137–145

    CAS  PubMed  Google Scholar 

  • Baker JR, O'Connor JP, Metcalf PA, Lawson MR, Johnson RN (1983) Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus. Br Med J 287:863–867

    CAS  Google Scholar 

  • Baker JR, Metcalf PA, Johnson RN, Newman D, Rietz P (1985) Use of protein-based standards in automated colorimetric determinations of fructosamine in serum. Clin Chem 31:1550–1554

    CAS  PubMed  Google Scholar 

  • Baker JR, Metcalf P, Tanell M, Lever M, Johnson R (1986) Quality assessment of determinations of serum fructosamine 33 clinical chemistry laboratories. Clin Chem 31:2133–2136

    Google Scholar 

  • Baxi L, Barad D, Reece A, Farber R (1984) Use of glycosylated hemoglobin as a screen for macrosomia in gestational diabetes. Obstet Gynecol 64:347–350

    CAS  PubMed  Google Scholar 

  • Cousins L, Dattel BJ, Hollingsworth DR, Zettner A (1984) Glycosylated hemoglobin as a screening test for carbohydrate intolerance in pregnancy. Am J Obstet Gynecol 150:455–460

    CAS  PubMed  Google Scholar 

  • Daubresse JC, Laurent E, Ligny C, Bailly A, Lemy C, Duchateau A, Meunier JC (1987) The usefulness of fructosamine determination in diabetic patients and its relation to metabolic control. Diabete Metabolisme (Paris) 13:217–221

    CAS  Google Scholar 

  • Feige A, Nössner U (1985) Das Verhalten des glycosylierten Hämoglobins (HbA1) in normaler und pathologischer Schwangerschaft. Z Geburtsh Perinat 189:13–16

    CAS  Google Scholar 

  • Flückiger R, Woodtli T, Berger W (1987) Evaluation of the fructosamine test for the measurement of plasma protein glycation. Diabetologia 30:648–652

    Article  PubMed  Google Scholar 

  • Frandsen EK, Sabagh T, Bacchus RA (1988) Serum fructosamine in diabetic pregnancy. Clin Chem 34:316–319

    CAS  PubMed  Google Scholar 

  • Freinkel N, Dooley SL, Metzger BE (1985) Care of the pregnant woman with insulin-dependent diabetes mellitus. N Engl J Med 313:96–101

    CAS  PubMed  Google Scholar 

  • Gain T, Henderkott U, Bottermann P (1981) Haemoglobin A1-Bestimmung beim oralen Glucosetoleranztest. Akt Endokrin 2:132–135

    CAS  Google Scholar 

  • Henrichs HR, Bonini P, Fielding L, Garcia-Betran L, Henny J, Kruse-Jarres JD, Schlebusch H, Schleicher ED, Sommer R, Steen G, Try K, Willms B (1989) Fructosamin als Routineparameter in der Diabeteskontrolle. Multizentrische, klinische Erproblung eines verbesserten Fructosamintestes. Akt Endokr Stoffw 10:96 (Abstract)

    Google Scholar 

  • Hofmann HMH (1989) Fructosamine in relation to maternofetal glucose and insulin homeostasis in gestational diabetes. Arch Gynecol Obstet 247:173–185

    Google Scholar 

  • Hohenauer L (1980) Intrauterine Wachstumskurven für den deutschen Sprachraum. Z Geburtsh Perinat 184:167–179

    CAS  Google Scholar 

  • Johnson RN, Metcalf PA, Baker JR (1982) Fructosamine: a new approach to the estimation of serum glycosylprotein. An index of diabetic control. Clin Chem Acta 127:87–95

    Google Scholar 

  • Jovanovic L, Peterson CM (1981) The clinical utility of glycosylated hemoglobin. Am J Med 70:331–338

    Article  CAS  PubMed  Google Scholar 

  • Kainer F, Rollett H, Hofmann HMH, Weiss PAM, Haas JG (1987) Orale Glukosebelastung (oGTT) mit 50 g, 1 g/kg Körpergewicht und 100 g, Pilot-Studie. In: Weiss PAM (ed) Probleme der Perinatalen Medizin: Kohlenhydratstoffwechselstörungen und Schwangerschaft. Maudrich, Vienna, pp 57–58

    Google Scholar 

  • Lemon M, Forrest AR (1986) Fructosamine activity of proteins in serum. Clin Chem 32:2101

    CAS  PubMed  Google Scholar 

  • Lim YS, Staley MJ (1985) Measurement of plasma fructosamine evaluated for monitoring diabetes. Clin Chem 31:731–733

    CAS  PubMed  Google Scholar 

  • Lim YS, Staley MJ (1986) Plasma fructosamine is a measure of all glycated proteins. Clin Chem 32:560

    Google Scholar 

  • Lind T, Cheyne GA (1979) Effect of normal pregnancy upon the glycosylated haemoglobins. Br J Obstet Gynecol 86:210–213

    CAS  Google Scholar 

  • Little RR, England JD, Wiedmeyer HM, McKenzie EM, Pettitt DJ, Knowler WC, Goldstein DE (1988) Relationship of glycosylated hemoglobin to oral glucose tolerance: implications for diabetes screening. Diabetes 37:60–64

    CAS  PubMed  Google Scholar 

  • Lloyd D, Marples J (1984) Simple colorimetry of glycated serum protein in a centrifugal analyzer. Clin Chem 30:1686–1688

    CAS  PubMed  Google Scholar 

  • Morris MA, Grandis AS, Litton J (1985) The correlations of glycosylated serum protein and glycosylated hemoglobin concentrations with blood glucose in diabetic pregnancy. Am J Obstet Gynecol 153:257–260

    CAS  PubMed  Google Scholar 

  • O'Shaughnessy R, Russ J, Zuspan FP (1979) Glycosylated hemoglobin and diabetes mellitus in pregnancy. Am J Obstet Gynecol 135:783–790

    PubMed  Google Scholar 

  • Pedersen JF, Molsted-Pedersen L, Mortensen HB (1984) Fetal growth delay and maternal hemoglobin A1c in early diabetic pregnancy. Obstet Gynecol 64:351–352

    CAS  PubMed  Google Scholar 

  • Peterson CM, Jovanovic L (1986) Glycosylated proteins in normal and diabetic pregnancy. Acta Endocrin [Suppl] 277:107–111

    CAS  Google Scholar 

  • Peterson CM, Jovanovic L (1988) Glycosylated proteins in normal and diabetic pregnancy. In: Gestational diabetes. Weiss PAM, Coustan DR (eds) Springer, Wien New York, pp 107–114

    Google Scholar 

  • Phleps RL, Honig GR, Green D, Metzger BE, Frederiksen MC, Freinkel N (1983) Biphasic changes in hemoglobin A1c concentrations during normal human pregnancy. Am J Obstet Gynecol 147:651–653

    Google Scholar 

  • Roberts AB, Baker JR (1986) Serum fructosamine: a screening test for diabetes in pregnancy. Am J Obstet Gynecol 154:1027–1030

    CAS  PubMed  Google Scholar 

  • Rodens K, Heinze E, Pohlandt F, Kerner W, Teller WM (1989) Eine retrospektive Untersuchung zur postpartalen Hypoglykämieneigung von Neugeborenen diabetischer Mütter. Akt Endokr Stoffw 10:122 (Abstract)

    Google Scholar 

  • Ryan EA, Stark R, Crockford PM, Suthijumroon A (1987) Assessment of value of glycosylated albumin and protein in detection of gestational diabetes. Diabetes Care 10:213–216

    CAS  PubMed  Google Scholar 

  • Schlösser RL, Küster M (1987) Fructosamine bei Neugeborenen-Referenzwerte. Fructosamine-Symposium Gallien R und Bottesch AG eds. Roche, Basel Grenzach-Wyhlen, pp 111–115

    Google Scholar 

  • Shah BD, Cohen AW, May C, Gabbe SG (1982) Comparison of glycohemoglobin determination and the one-hour oral glucose screen in the identification of gestational diabetes. Am J Obstet Gynecol 144:774–777

    CAS  PubMed  Google Scholar 

  • Thurnheer U, Hess T, Degiampietro P, Peheim E (1988) Die Fructosaminbestimmung als Screeninguntersuchung für Diabetes mellitus mit akuter koronarer Herzkrankheit. Schw Med Wochenschr 118:267–270

    CAS  Google Scholar 

  • Wagner R, Löwenstein I, Gieshoff B, Graben N, Olbricht Th, Windeck R, Benker G, Reinwein D (1987) Beurteilung der Stoffwechsellage niereninsuffizienter Diabetiker mit dem Fructosamin-Test. Dtsch Med Wochenschr 112:175–177

    CAS  PubMed  Google Scholar 

  • Weiss PAM, Pürstner P, Winter R, Lichtenegger W (1984) Insulin levels in amniotic fluid of normal and abnormal pregnancies. Obstet Gynecol 63:371–375

    CAS  PubMed  Google Scholar 

  • Weiss PAM, Hofmann HMH (1985) Diabetes mellitus und Schwangerschaft. In: Burghardt E (ed) Spezielle Gynäkologie und Geburtshilfe mit Andrologie und Neonatologie. Springer, Wien New York, pp 337–427

    Google Scholar 

  • Weiss PAM (1988) Gestational diabetes: A survey and the Graz approach to diagnosis and therapy. In: Weiss PAM, Coustan DR (eds) Gestational diabetes. Springer, Wien New York, pp 1–55

    Google Scholar 

  • Widness JA, Schwartz HC, Kahn CB, Oh W, Schwartz R (1980) Glycohemoglobin in diabetic pregnancy: a sequential study. Am J Obstet Gynecol 136:1024–1029

    CAS  PubMed  Google Scholar 

  • Willms B, Nagel Ch (1989) Zur Beurteilung der Kohlenhydratstoffwechsellage mittels Fructosamin ist der Bezug auf Serum-Gesamteiweiß erforderlich. Akt Endokr Stoffw 10:144 (Abstract)

    Google Scholar 

  • Winocour PH, Bhatnagar D, Reed P, Dhar H (1987) Does the measurement of serum fructosamine accurately reflect levels of glycated albumin in insulin-dependent diabetes? Ann Clin Biochem 24:47–52

    PubMed  Google Scholar 

  • Yue DK, Morris K, Lennan SMC, Turtle JR (1989) Glycosylation of plasma protein and its relation to glycosylated hemoglobin. Diabetes 29:296–300

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Graz, Austria

    H. M. H. Hofmann

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  1. H. M. H. Hofmann
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Hofmann, H.M.H. Maternal serum fructosamine and maternofetal glucose and insulin homeostasis in normal pregnancy. Arch Gynecol Obstet 248, 1–11 (1990). https://doi.org/10.1007/BF02389583

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  • DOI: https://doi.org/10.1007/BF02389583

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