Radioprotective effects of glutathione on molecular systems

  • R. Badiello
  • G. C. Ceschel
  • B. Esposito
Letter to the Editor

Abstract

The paper investigates the effect of glutathione on model biological systems, such as enzymes, (lisozyme, alcoholdehydrogenase, α-chymotrypsin) and DNA base components. Our results on the inactivation of enzymes and on the chemical changes in DNA base components show a radioprotective action of glutathione in all systems. The results are discussed in terms of glutathione free radical reactivity and in the light of current hypothesis on the modification of the radiation damage given by thiol compounds.

Keywords

Radiation Enzyme Physical Chemistry Inorganic Chemistry Glutathione 

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Copyright information

© Akadémiai Kiadó 1998

Authors and Affiliations

  • R. Badiello
    • 1
  • G. C. Ceschel
    • 2
  • B. Esposito
    • 1
  1. 1.Unitr Complessa di Scienze Chimiche, Radiochimiche e MetallurgicheUniversitŕ di BolognaBolognaItaly
  2. 2.Dipartimento di Scienze FarmaceuticheUniversitŕ di BolognaBolognaItaly

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