Skip to main content

Subependymal giant-cell astrocytoma associated with tuberous sclerosis: Case report


Tuberous sclerosis is a neurocutaneous syndrome with a wide variety of clinical, pathologic, and radiologic manifestations. Intracranial phakomatosis has been reported to include subependymal nodules; cortical tubers, and subependymal giant-cell astrocytomas. Subependymal giant-cell astrocytomas are rare, benign brain tumors of unknown histogenesis which cause increased intracranial pressure, seizures, and focal neurologic signs. The only treatment of these tumors is total surgical removal, because they are not sensitive to irradiation and chemotherapy. We report a patient with tuberous sclerosis who underwent surgery for a large subependymal giant-cell astrocytoma.

This is a preview of subscription content, access via your institution.


  1. Akluwalia CK, PT Chandrasoma: Cytomorphology of subependymal giant cell astrocytoma. A case report. Acta Cytol 37 (1993) 197–200

    Google Scholar 

  2. Altermatt HT, BW Scheithauer: Cytomorphology of subependymal giant-cell astrocytoma. Acta Cytol 36 (1992) 171–175

    CAS  PubMed  Google Scholar 

  3. Bell DG, BF King, RR Hattery, et al: Imaging characteristics of tuberous sclerosis. AJR 156 (1991) 1081–1086

    CAS  PubMed  Google Scholar 

  4. Boesel CP, GW Paulson, EJ Kosnik, et al: Brain hamartomas and tumors associated with tuberous sclerosis. Neurosurgery 4 (1979) 410–417

    CAS  PubMed  Google Scholar 

  5. Chow CW, GL Klug, EA Lewis: Subependymal giant cell astrocytoma in children. An unusual discrepancy between histological and clinical features. J Neurosurg 68 (1988) 880–883

    CAS  PubMed  Google Scholar 

  6. Fujiwara S, T Takaki, T Hikita, et al: Subependymal giant cell astrocytoma associated with tuberous sclerosis. Do subependymal nodules grow? Childs Nerv System 5 (1989) 43–44

    CAS  Google Scholar 

  7. Gomez MR: Tuberous Sclerosis. New York. Raven Press 1979

    Google Scholar 

  8. Gomez MR: Factors determining outcome in tuberous sclerosis. Int Pediatr 4 (1989) 127

    Google Scholar 

  9. Margo CE, JP Barletta, JA Staman: Giant cell astrocytoma of the retina in tuberous sclerosis. Retina 13 (1993) 155–159

    CAS  PubMed  Google Scholar 

  10. Menor F, L Marti-Bonmati, F Mulas, et al: Neuroimaging in tuberous sclerosis: a clinicoradiological avaluation in pediatric patients. Pediatr Radiol 22 (1992) 485–489

    Article  CAS  PubMed  Google Scholar 

  11. Oikawa S, K Sakamoto, N Kobayashi: A neonatal huge subependymal giant cell astrocytoma: case report. Neurosurgery 35 (1994) 748–750

    CAS  PubMed  Google Scholar 

  12. Painter MJ, D Pang, M Ahdab-Barmada, et al: Connatal brain tumors in patient with tuberous sclerosis. Neurosurgery 14 (1984) 570–573

    CAS  PubMed  Google Scholar 

  13. Shepherd CW, BW Scheithauer, MR Gomez, et al: Subependymal giant cell astrocytoma: A clinical, pathological, and flowcytometric study. Neurosurg 28 (1991) 864–868

    CAS  Google Scholar 

  14. Tanaka J, S Kawakami, K Hashimoto: Immunocytochemistry of subependymal giant cell astrocytoma associated with tuberous sclerosis (in Japanese). No To Hattatsu 21 (1989) 222–226

    CAS  PubMed  Google Scholar 

  15. Winter J: Computed tomography in diagnosis of intracranial tumors versus tubers in tuberous sclerosis. Acta Radiol 23 (1982) 337–344

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ergün, R., Ökten, A.İ., Yaman, M. et al. Subependymal giant-cell astrocytoma associated with tuberous sclerosis: Case report. Neurosurg. Rev. 21, 185–188 (1998).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:


  • Cerebral tumor
  • subependymal giant-cell astrocytoma
  • tuberous sclerosis