Biomedical Engineering

, Volume 33, Issue 5, pp 221–225 | Cite as

Nonuniform dose distribution in normal organs and tissues during radiation therapy of malignant tumors

  • L. Ya. Klepper
Research, Design, And Technology


1. The probability of postradiation complications caused by the same total dose is lower in case of the uniform dose distribution.

2. If ω is close to .1, the irradiated tissue can be regarded as a system consisting of independent elementary volumes. The probability of postradiation complications in each elementary volume does not depend (or depends only slightly) on the dose distribution in other elementary volumes and the total volume of irradiated tissue.

3. If the equivalent dose decreases with increasing volume of irradiated tissue, the parameter ω for this tissue is more than 1.

4. The dimensionless parameter ω=A2 ·b can be regarded as a measure of the tissue ability for recovery. The greater is ω, the more flattened is the curveP(D) until reaching its point of inflection.

This work was supported by the Russian Foundation for Basic Research (project No. 980100057).


Radiation Malignant Tumor Total Dose Dimensionless Parameter Elementary Volume 
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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • L. Ya. Klepper
    • 1
  1. 1.Central Institute of Mathematical EconomicsRussian Academy of SciencesMoscow

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