Pediatric Radiology

, Volume 17, Issue 4, pp 308–313 | Cite as

131I-Meta-iodobenzylguanidine scintigraphy in patients with neuroblastoma

  • S. Hibi
  • S. Todo
  • S. Imashuku
  • T. Miyazaki


Twenty-six studies by meta-(131I)-iodobenzylguanidine scintigraphy (131I-MIBG), 26 studies by67Ga-citrate and 3399mTc-hydorxymethylene diphosphate (99mTc-HMDP) scintigraphic studies were performed for 10 patients with abdominal neuroblastoma. Comparing the131I-MIBG images obtained at 24, 48 and 72 h, the 48-h image was the most distinctive for the tumor. Intrabdominal primary lesions, which ranged from bean to fist-size, were visualized in 7/7 cases (100%) by131I-MIBG, 4/7 cases (57%) by67Ga-citrate and 4/8 cases (50%) by99mTc-HMDP before surgery and at diagnosis. In serial follow-up of these patients after starting chemotherapy,131I-MIGB detected 100% of regressing primary tumors. Studies of 5 postoperative patients showed negative images for the primary tumor in all 3 scintigraphies except one in whom131I-MIBG was positive, but not67Ga-citrate or99mTc-HMDP, for an unresectable residual tumor.131I-MIBG also detected metastatic lesions not predicted by67Ga-citrate or99mTc-HMDP and reflected tumor progression more sensitively than known tumor markers such as urinary vanillylmandelic acid (VMA), homovanillic acid (HVA), serum neuron-specific enolase (NSE) and ferritin. These findings indicate that the 48 hr131I-MIBG scintigraphy is superior to67Ga-citrate or99mTc-HMDP images and to other biochemical markers in monitoring the effect of treatment on neuroblastoma.


Primary Tumor Ferritin Neuroblastoma Diphosphate Residual Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • S. Hibi
    • 2
  • S. Todo
    • 2
  • S. Imashuku
    • 2
  • T. Miyazaki
    • 1
  1. 1.Department of RadiologyKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Department of PediatricsKyoto Prefectural University of MedicineKyotoJapan

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