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Axoplasmic transport blockage therapy in herpes zoster ophthalmicus

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

Three patients with herpes zoster ophthalmicus were treated with an oral administration of colchicine and corticosteroid, while another seven were given systemic corticosteroid, vitamins, and sedatives.

Colchicine inhibited the formation of new skin lesions but did not suppress the already grown vesicles. The effect of colchicine was attributed to a blockage of intra-axonal dissemination by neurotrophic virus.

Zusammenfassung

Blockade des axoplasmatischen Transportes als Therapie beim Herpes zoster ophthalmicus.

3 Patienten mit Herpes zoster ophthalmicus wurden durch orale Gaben von Colchizin und Corticosteroiden behandelt, während eine andere Gruppe von 7 Patienten nur Corticosteroide und Vitamine und Sedativa erhielten.

Colchizin verhütet die Bildung neuer Hautblasen, konnte jedoch nicht die bereits vorhandenen unterdrücken. Der Effekt des Colchizins wird zurückgeführt auf eine Blockade des intraaxonalen Transportes des neurotropen Virus.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Kyoto University, Syogoin, Sakyo-ku, 606, Kyoto, Japan

    Etsuo Chihara

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  1. Etsuo Chihara
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Chihara, E. Axoplasmic transport blockage therapy in herpes zoster ophthalmicus. Albrecht v Graefes Arch. klin. exp. Ophthal. 211, 183–186 (1979). https://doi.org/10.1007/BF02387423

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  • DOI: https://doi.org/10.1007/BF02387423

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