Electron-microscopic analysis of iris vessels in two cases of uveitis

  • Kazuo Mukuno
  • Rudolf Witmer
  • Peter Gruber


Electron-microscopic analysis of iris biopsy material was carried out paying particular attention to vessels and infiltrating cells. Characteristic changes of vessels and cells were found in two cases. One showed abundant lymphodiapedesis, perivascular infiltration, and vessels appearing morphologically normal. The other showed diffuse infiltration of cells and numerous fenestrated newly formed vessels. In the latter, three different types of opening in the endothelium were observed: (1) separation of intercellular junctions; (2) small pores or defects in the endothelium, and (3) large holes or defects in the endothelium. Cell leakage from normal and newly formed vessels was considered. We concluded that lymphocytes may migrate through the cytoplasm within membrane-bounded vesicles in normal vessels, whereas in newly formed fenestrated vessels cells, including small lymphocytes, may pass through three different types of opening in the endothelium.


Public Health Uveitis Characteristic Change Infiltrate Cell Biopsy Material 
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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Kazuo Mukuno
    • 1
  • Rudolf Witmer
    • 2
  • Peter Gruber
    • 2
  1. 1.Department of Ophthalmology, School of MedicineKitasato UniversitySagamihara-cityJapan
  2. 2.Department of OphthalmologyUniversity of ZürichZürichSwitzerland

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