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Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma

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Abstract

Investigation on electrophilic attaching of astatine-211 to methylene blue is carried out. Conditions for transferring astatine to a chemically active electrophilic form were found. A method for the production of astatine-211-tagged methylene blue has been developed. The resulting radiopharmaceutical preparation is free of the nonisotopic iodine carrier. The chromatographic method of purifying simultaneously the product by anion-exchange resin QAE-Sephades A-25 allows it to pass into a 0.9% solution of sodium chloride (physiological salt solution). The method provides the radiochemical yield of astatine-211-tagged methylene blue as large as 68±6%.

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References

  1. D. Pectasides et al., Br. J. Cancer, 53 (1986) 727.

    CAS  Google Scholar 

  2. D. J. Hnatowich et al., Science, 220 (1983) 613.

    CAS  Google Scholar 

  3. R. M. Reilly, G. N. Ege, J. Label. Comp. Radiopharm., 24 (1987). No. 5, 541.

    Google Scholar 

  4. Z. Szucz, Z. Milesz, Yu. V. Norseev, L. Vasaros, Europ. J. Nucl. Med. 21 (1994) No. 10, 128.

    Google Scholar 

  5. Z. Milesz, Yu. V. Norseev, Z. Szucz, L. Vasaros, Radiokhimiya, 37 (1995) No. 3, 253.

    CAS  Google Scholar 

  6. I. Brown, R. N. Carpenter, E. Link, J. S. Mitchell, J. Radioanal. Nucl. Chem., 107 (1986) 337.

    CAS  Google Scholar 

  7. A. M. Potts, Trans. Am. Ophthalmol. Soc., 60 (1962) 517.

    CAS  Google Scholar 

  8. E. M. Link, I. Brown, R. N. Carpenter, J. S. Mitchell, Cancer Res. 49 (1989) No. 15, 4332.

    CAS  Google Scholar 

  9. E. M. Link, R. N. Carpenter, Cancer Res., 50 (1990) No. 10, 2963.

    CAS  Google Scholar 

  10. L. Vasaros, Yu. V. Norseev, V. A. Khalkin, Dokl. Akad. Nauk. SSSR, (1982) 120.

  11. L. Vasaros, Yu. V. Norseyev, D. D. Nhan, V. A. Khalkin, Radiochem. Radioanal. Letters, 54 (1982) 239.

    CAS  Google Scholar 

  12. Yu. V. Norseev, D. D. Nhan, V. A. Khalkin, N. Q. Huan, L. Vasaros, J. Radional. Nucl. Chem., 94 (1985) 185.

    CAS  Google Scholar 

  13. Z. Szucz, Z. Milesz, Yu. V. Norseyev, L. Vasaros, European J. Nucl. Med. 21 (1994) No. 10, 128.

    Google Scholar 

  14. Yu. V. Norseyev, N. L. Shmakova, Nukleonika, 40 (1995) No. 1, 13.

    CAS  Google Scholar 

  15. V. Doberentz et al., Radiochem. Radioanal. Letters, 52 (1982) No. 2, 119.

    Google Scholar 

  16. J. A. Smit, J. A. Myburgh, R. D. Neirinckx, Clin. Exp. Immunol., 14 (1973) 107.

    CAS  Google Scholar 

  17. C. Aajl, W. R. J. M. Tschroots, L. Lindner, T. E. W. Feltkamp, Int. J. Appl. Radiat. Isotopes, 26 (1975) 25.

    Google Scholar 

  18. P. B. D. De la Mare, J. H. Ridd, Aromatic substitution. Nitration and halogenation. — New York, Academic Press, 1959, 252 pp.

    Google Scholar 

Download references

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  1. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia

    Yu. V. Norseev

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  1. Yu. V. Norseev
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Norseev, Y.V. Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma. J Radioanal Nucl Chem 237, 155–158 (1998). https://doi.org/10.1007/BF02386681

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  • DOI: https://doi.org/10.1007/BF02386681

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