Pediatric Radiology

, Volume 16, Issue 2, pp 107–109 | Cite as

Hepatic imaging in Stage IV-S neuroblastoma

  • E. A. FrankenJr.
  • W. L. Smith
  • M. D. Cohen
  • C. T. Kisker
  • C. E. Platz
Originals

Abstract

Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies.

Keywords

Neuroblastoma Technetium Image Investigation Diffuse Type Tumor Spread 

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References

  1. 1.
    Puri S, Spencer RP (1978) Hepatic scans in spontaneous regression of neuroblastoma. Int J Nucl Med Biol 5: 129PubMedGoogle Scholar
  2. 2.
    Stevens MM (1979) Stage IV-S neuroblastoma: disseminated malignancy with a favourable prognosis, three case reports. Aust Paediatr J 15:39PubMedGoogle Scholar
  3. 3.
    Evans AE, Chatten J, D'Angio GJ, Gerson JM, Robinson J, Schnaufer L (1980) A review of 17 IV-S neuroblastoma patients at the Children's Hospital of Philadelphia. Cancer 45: 833PubMedGoogle Scholar
  4. 4.
    Bond J (1982) Neuroblastoma in infants. In: Pochedly C (ed) Neuroblastoma, clinical and biological manifestations. Elsevier Biomedical, New York, p 1Google Scholar
  5. 5.
    Hamdouch M, Harmann O, Garel L, Sauvegrain J (1982) Radiological diagnosis and particularities of neonatal neuro-blastoma (Pepper's syndrome excluded). Ann Radiol (Paris) 25: 5Google Scholar
  6. 6.
    Jaffe N (1982) Biologic vagaries in neuroblastoma. In: Pochedly C (ed) Neuroblastoma, clinical and biological manifestations. Elsevier Biomedical, New York, p 293Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • E. A. FrankenJr.
    • 1
    • 5
  • W. L. Smith
    • 1
    • 2
  • M. D. Cohen
    • 4
  • C. T. Kisker
    • 2
  • C. E. Platz
    • 3
  1. 1.Department of RadiologyUniversity of Iowa College of MedicineIowa City
  2. 2.Department of PediatricsUniversity of Iowa College of MedicineIowa City
  3. 3.Department of PathologyUniversity of Iowa College of MedicineIowa City
  4. 4.Department of Pediatric RadiologyJames Whitcomb Riley HospitalIndianapolisUSA
  5. 5.Department of RadiologyUniversity of Iowa HospitalsIowa CityUSA

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