In vivo total body chlorine measurements using prompt-gamma neutron activation analysis

  • R. J. Shypailo
  • K. J. Ellis
Applications of Radioanalytical Methods to Biological and Clinical Systems


Total body chlorine (TBC1) provides an estimate of extracellular water. We have examined the feasibility of measuring TBC1 using the 5.6, 6.1, and 8.6 MeV C1 peaks produced during in vivo prompt-gamma neutron activation (dose<0.3 mSv). In subjects, background interference permitted the use of only the 8.6 MeV peak in C1 analysis. Preliminary analyses of the prompt-gamma spectra for 33 healthy females (ages: 24–40 yr) provided a mean estimate of 0.85 g C1 per kg body weight. It is therefore feasible to measure TBC1 concurrently with body nitrogen using relatively low-dose prompt-gamma neutron activation analysis.


Nitrogen Body Weight Physical Chemistry Inorganic Chemistry Chlorine 
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Copyright information

© Akadémiai Kiadó 1998

Authors and Affiliations

  • R. J. Shypailo
    • 1
  • K. J. Ellis
    • 1
  1. 1.USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Body Composition LaboratoryBaylor College of MedicineHoustonUSA

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