Summary
Metoclopramide has previously been shown to inhibit the ketosis of starvation in rats and humans. The effect of D2-dopaminergic blockade on post-exercise ketosis was, therefore, studied in 6 carbohydrate-starved non-athletic persons who had just completed a 9-km walk in mountainous terrain. There were nine control subjects who went on the walk, but who did not ingest metoclopramide. Metoclopramide (0.15 mg·kg−1 body mass) caused a highly significant rise in the plasma prolactin concentration, but did not influence blood concentrations of 3-hydroxybutyrate, free fatty acid, glucose, insulin or glucagon. Unlike ketosis in starvation, therefore, neither prolactin, nor the D2-dopaminergic system play a part in the genesis of post-exercise ketosis.
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References
Adams JH, Irving G, Koeslag JH, Lochner J de V, Sandell RC, Wilkinson C (1987)β-Adrenergic blockade restores glucose's antiketogenic activity after exercise in carbohydrate-starved athletes. J Physiol (Lond) 386:439–454
Bahnsen M, Burrin JM, Johnston DG, Pernet A, Walker M, Alberti KGMM (1984) Mechanisms of catecholamine effect on ketogenesis. Am J Physiol 247:E173-E180
Blesa-Malpica G, Johnston DG, Burrin JM, Orskov H, Heath AB, Alberti KGMM (1981) Dopaminergic control of ketogenesis in fasting. Clin Endocrinol 14:479–484
Burrin JM, Farrer M, Alberti KGMM (1982) Effects of catecholamines on ketogenesis in isolated hepatocytes from fed or 48-h starved rats. Biochem Soc Trans 10:274–275
Dole VP, Meinertz A (1960) Microdetermination of long chain fatty acids in plasma and tissues. J Biol Chem 235:2595–2599
Fourie AJ, Millar R, Child P, Hickman R (1987) Sustained feeding or fasting affects levels of glucagon (IRG) in porcine plasma, gut, and pancreas. Scand J Gastroenterol 22 [Suppl 138]:1–19
Johnson RH, Rennie MJ (1973) Changes in fat and carbohydrate metabolism caused by moderate exercise in patients with acromegaly. Clin Sci 44:63–71
Johnson RH, Rennie MJ, Walton JL, Webster MHC (1971) The effect of moderate exercise on blood metabolites in patients with hypopituitarism. Clin Sci 40:127–136
Johnson RH, Sulaiman WR, Webster MHC (1972) Human growth hormone and ketosis in athletes and non-athletes. Nature 236:119–120
Johnston DG, Pernet A, McCulloch A, Blesa-Malpica G, Burrin JM, Alberti KGMM (1982) Some hormonal influences on glucose and ketone body metabolism in normal human subjects. In: Porter R, Lawrenson G (eds) Metabolic Acidosis. (Ciba Foundation Symposium 1987). Pitman, London, pp 168–184
Johnston DG, Blesa-Malpica G, Burrin JM, Waugh C, Cook D, Orskov H, Alberti KGMM (1983) Dopamine blockade inhibits starvation ketosis in man. Clin Endocrinol 19:389–396
Koeslag JH, Levinrad LI, Lochner J de V, Sive AA (1985) Post-exercise ketosis in post-prandial exercise: effect of glucose and alanine ingestion in humans. J Physiol (Lond) 358:395–403
Vahed YAK, Koeslag JH, Lochner J de V (1988) Beta-adrenergic blockade counteracts starvational ketosis, but aggravates post-exercise ketosis in non-athletes. J Endocrinol 119:167–171
Williamson DH, Mellanby J, Krebs HA (1962) Enzymic determination of D(—)-β-hydroxybutyric acid and acetoacetic acid in blood. Biochem J 82:90–96
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Vahed, Y.A.K., Koeslag, J.H. & Lochner, J.d.V. D2-dopaminergic blockade does not influence post-exercise ketosis in non-athletes. Europ. J. Appl. Physiol. 59, 174–177 (1989). https://doi.org/10.1007/BF02386183
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DOI: https://doi.org/10.1007/BF02386183