Abstract
Due to the fact that no effective conditioning agent for hemodynamically unstable donors exists, the number of suitable donors is limited. The efficacy of OP-41483, a stable analog of prostaglandin I2, as a conditioning agent of the liver was investigated in this study using pigs. OP-41483 was administered via the portal tributary for 10 min before 30 min of warm ischemia. Graft livers were procured after perfusion with OP-41483 in cold normal saline, the flushed with OP-41483 in Euro-Collins solution and placed in cold storage prior to orthotopic transplantation. OP-41483 was also administered intraportally for 120 min after reperfusion. Biochemical and histological studies, and survival rates were compared with a control group not given OP-41483 in an otherwise similar experimental protocol. The graft function recovered better in the OP group than in the control group, shown by the lactate values and lactate-to-pyruvate ratios. The marked congestion noted in the parenchyma of the control group livers was minimal in the OP group, verifying the microcirculatory effect of prostaglandin I2 by its vasodilatory and antithrombotic actions. These findings suggest that OP-41483 has some protective effect as a conditioning agent in liver transplantation, with timing of administration being crucial.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tarnawski A, Brzozowski T, Sarfehl J (1988) Prostaglandin protection of human isolated gastric glands against indomethacin and ethanol injury. J Clin Invest 81:1081–1089
Araki H, Lefer AM (1980) Cytoprotective actions of prostacyclin during hypoxia in the isolated perfused cat liver. Am J Physiol 238:176–181
Toledo-Pereyra LH (1984) Role of prostaglandins (PGI2) in improving the survival of ischemically damaged liver allografts. Trans Am Soc Artif Intern Organs 30:390–394
Todo S, Yokoi H, Podesta L, ChapChap P, Pan C, Okuda K, Kamiyama Y, Demetris J, Makowka L, Iwatsuki S, Starzl E (1988) Amelioration of normothermic canine liver ischemia with prostacyclin. Transplant Proc 20:965–968
Steininger R, Muhalbacher H, Rauhs R, Roth E, Bursch W (1988) Protective effect of PGI2 and diltiazem on liver ischemia and reperfusion in pigs. Transplant Proc 20:999–1002
Morimoto T, Ozawa K, Isselhard W (1992) Conversion of mitochondrial redox state toward oxidation by prostacyclin in 70%-hepatectomized rats. Res Exp Med 192:161–168
David A, Ujhelyi E, Jeny A, Lapis K, Institoris L (1985) Hepatoprotective effects of prostacyclins on CC14 induced liver injury in rats. Exp Mol Pathol 42:163–166
Lifschitz M, Barnes J (1984) Prostaglandin I2 attenuation ischemic renal failure in the rat. Am J Physiol 247:F714-F717
Kaufman RP, Anner H, Kobzik L (1987) Vasodilating prostaglandins prevent renal damage after ischemia. Ann Surg 205:195–198
Greig P, Woolf G, Sinclair S, Abecassis M, Strasberg S, Taylor B, Blendis L, Superina R, Glynn M, Langer B, Levy G (1989) Treatment of primary liver graft nonfunction with prostaglandin E1. Transplantation 48:447–453.
Vargas A, Krishnamurthi V, Masih R, Robinson A, Schulak J (1995) Prostaglandin E1 attenuation of ischemic renal reperfusion injury in the rat. J Am Coll Surg 180:713–717
Olthoff K, Wasef E, Seu P (1991) PGE1 reduces injury in hepatic allografts following preservation. J Surg Res 50:595–601
Fujitani B, Wakitani K (1990) Studies on antiplatelet effects of OP-41483, a prostaglandin I2 analog, in experimental animals. Jpn J Pharmacol 53:25–33
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kishida, A., Kurumi, Y. & Kodama, M. Efficacy of prostaglandin I2 analog on liver grafts subjected to 30 minutes of warm ischemia. Surg Today 27, 1056–1060 (1997). https://doi.org/10.1007/BF02385788
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02385788