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Influence of various anesthetic drugs on the intraocular pressure of cats

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Summary

Cats with one normal eye and one eye with experimental glaucoma were trained to tolerate tonometry while conscious. They were then given the general anesthetic agents pentobarbital, ketamine, and CI-744 in the lowest and twice the lowest dosages which permitted tonometry in untrained cats. Pentobarbital lowered intraocular pressure (IOP) by 20–50%. Ketamine raised IOP by about 10%. CI-744 had essentially no effect on IOP. The two components of CI-744, tiletamine (CI-634) and zolazepam (CI-716) were given individually in the doses in which they had been given as part of CI-744. Tiletamine had no effect on IOP, while zolazepam lowered IOP by about 10%.

Zusammenfassung

Katzen mit einem normalen und einem Auge mit experimentellem Glaukom, wurden trainiert, eine Tonometrie in wachem Zustand zu tolerieren.

Die Narkotika: Pentobarbital, Ketamine and CI-744 wurden dann in der niedrigsten (und der doppelten dieser) Dosis injiziert, die gerade noch eine Tonometrie bei untrainierten Katzen erlaubt.

Pentobarbital senkte den intraocularen Druck (IOD) um 20–50%. Ketamine erhöhte ihn um 10%, während CI-744 keinen wesentlichen Effekt auf den IOD hatte. Die zwei Komponenten von CI-744, Tiletamine (CI-634) und Zolazepam (CI-716) wurden in der Dosis injiziert, in der sie als Teile von CI-744 vorlagen. Tiletamine hatte keinen Effekt, während Zolazepam den IOD um 10% senkte.

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References

  • Bárány, E. H., Rohen, J. W.: Glaucoma in monkeys. Arch. Ophthal.69, 630–641 (1963)

    PubMed  Google Scholar 

  • Beck, C. C., Dresner, A. J.: VETALAR (ketamine hydrochloride, CI-581) a cataleptoid anesthetic agent for primate species. Presented at the 52nd Conference of Research Workers in Animal Diseases, Chicago, Ill., 1971

  • Becker, B., Krupin, Th., Podos, S. M.: Phenobarbital and aqueous humour dynamics: effect in rabbits with intact and transected optic nerves. Amer. J. Ophthal.70, 686–690 (1972)

    Google Scholar 

  • Bill, A.: Personal communication.

  • Corssen, G., Domino, E. F.: Dissociative anaesthesia: Further pharmacological studies and first clinical experience with phencyclidine derivate CI-581. Anesth. and Analg.45, 29–39 (1966)

    CAS  Google Scholar 

  • Corssen, G., Hoy, E. J.: A new parental anesthetic CI-581: Its effect on intraocular pressure. Pediat. Ophthal.4, 20 (1967)

    Google Scholar 

  • De Roetth, A. Jr., Schwartz, H.: Aqueous humour dynamics in glaucoma. Arch. Ophthal.55, 755–762 (1956)

    Google Scholar 

  • Eakins, K. E.: A comparative study of intraocular pressure and gross outflow facility in cat eyes during anesthesia. Exp. Eye Res.8, 106–115 (1969)

    CAS  PubMed  Google Scholar 

  • Kornblueth, W., Aladjemoff, L., Magora, F., Gabbary, A.: Influence of general anaesthesia on intraocular pressure in man. Arch. Ophthal.61, 84–87 (1959)

    CAS  Google Scholar 

  • Langham, M., McCarthy, E.: A rapid pneumatic applanation tonometer. Arch. Ophthal.79, 389–399 (1968)

    CAS  PubMed  Google Scholar 

  • Lehmann, R. A. W., Krupin, I., Podos, S. M.: Experimental effect of intracranial hypertension upon intraocular pressure. J. Neurosurg.36, 60–66 (1972)

    Google Scholar 

  • Schmiedeberg, W., Thiel, H. J., Zwieten, P. A. van: The influence of drugs involved in general anaesthesia and of antihypertensive agents on intraocular and blood pressure in the rabbit. Albrecht v. Graefes Arch. klin. exp. Ophthal.183, 179–195 (1971)

    Article  CAS  Google Scholar 

  • Schreuder, M., Linssen, G. H.: Intra-ocular pressure and anaesthesia. Anaesthesia27(2), 165–170 (1972)

    CAS  PubMed  Google Scholar 

  • Stone, H. H., Prijot, E. L.: The effect of barbiturate and paraldehyde on aqueous humor dynamics in rabbits. Arch. Ophthal.54, 834–840 (1955)

    CAS  Google Scholar 

  • Whyte, S. R., Shapiro, H. M., Turner, P., Harris, A. B.: Ketamine-induced intracranial hypertension. Anesthesiology36(2), 174–176 (1972)

    Google Scholar 

  • Wong, D. H. W., Jenkins, L. C.: Experimental study of mechanism of action of Ketamine on the central nervous system. Canad. Anaesth. Soc. J.21(1), 57–67 (1974)

    CAS  PubMed  Google Scholar 

  • Yoshikawa, K., Yasuichi, M.: The effect of ketamine on the IOP in children. Anesth. Analg. Curr. Res.50(2), 199–202 (1971)

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Pharmacology, University of Uppsala, Uppsala

    Rudolph W. Hahnenberger M.D.

  2. Universitäts-Augenklinik, D-7400, Tübingen, Federal Republic of Germany

    Rudolph W. Hahnenberger M.D.

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  1. Rudolph W. Hahnenberger M.D.
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Additional information

Supported by grant EY 00231-10 to Professor E. Bárány from the National Eye Institute, US PHS, and a training grant no. 402-023-903-4 from Deutscher Akademischer Austauschdienst, Bonn.

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Hahnenberger, R.W. Influence of various anesthetic drugs on the intraocular pressure of cats. Albrecht von Graefes Arch. Klin. Ophthalmol. 199, 179–186 (1976). https://doi.org/10.1007/BF02385214

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  • DOI: https://doi.org/10.1007/BF02385214

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