Experimental fibroplasia in the rabbit vitreous

Effects of hyaluronidase and implantation of autologous dermal tissue
  • Peep Algvere
  • Erik Kock


Intravitreal implantation of dermal connective tissue in rabbits caused a fibroplasia resulting in vitreous retraction, retinal detachment, and traction of nervous tissue from the optic nerve into the vitreous space.

Following implantation into eyes with an intact vitreous the incidence of retinal detachment was low (2 eyes of 12). When the hyaluronic acid of the vitrous was degraded by hyaluronidase prior to implantation, 9 eyes of 12 developed a progressive detachment of the retina, usually within one or two months. Intravitreal fibroplasia was found to be an important pathogenic factor causing detachment of the retina.


Retina Connective Tissue Optic Nerve Hyaluronic Acid Retinal Detachment 
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Autologes Bindegewebe aus der Haut von Kaninchen wurde in den Glaskörper der Tiere implantiert. Das kleine Bindegewebsstückchen verursachte eine Fibroplasie mit Glaskörperschrumpfung, Netzhautablösung und Traktion des Nervus opticus in den Glaskörperraum herein.

Nach Implantation in Augen mit intaktem Glaskörper entwickelte sich nur selten, in 2 von 12 Augen, eine Netzhautablösung. Nachdem die Hyaluronsäure des Glaskörpers mit Hyaluronidase ausgeschaltet worden war, konnte in 9 von 12 Augen eine progressive Ablösung der Netzhaut beobachtet werden.

Offenbar war die intravitreale Fibroplasie ein wichtiger pathogenetischer Faktor für die Entwicklung einer Netzhautablösung.


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  1. Balazs, E. A., Holmgren, Hj.: Wound extracts and their effects on the growth of hen fibroblasts. Nature (Lond.)163, 488 (1949)Google Scholar
  2. Constable, I. J., Oguri, M., Chesney, C. M., Swann D. A., Colman, R. W.: Platelet-induced vitreous membrane formation. Invest. Ophthal.12, 680 (1973)PubMedGoogle Scholar
  3. Darzynkiewicz, Z., Balazs, E. A.: Effect of connective tissue intercellular matrix on lymphocyte stimulation. I. Suppression of lymphocyte stimulation by hyaluronic acid. Exp. Cell Res.66, 113 (1971)PubMedGoogle Scholar
  4. Fowlks, W. L.: Meridional flow from the corona ciliaris through the pararetinal zone of the rabbit vitreous. Invest. Ophthal.2, 63 (1971)Google Scholar
  5. Freilich, D. B., Lee, P. F., Freeman, H. M.: Experimental retinal detachment. Arch. Ophthal.76, 432 (1966)PubMedGoogle Scholar
  6. Hayreh, S. S.: Posterior drainage of the intraocular fluid from the vitreous. Exp. Eye Res.5, 123 (1966)Google Scholar
  7. Lam, K. W., Ashrafzadeh, M. T., Lee, C. B.: Vitreous membranes. Induction in rabbits by intravitreous leukocyte injections. Arch. Ophthal.88, 655 (1972)PubMedGoogle Scholar
  8. Regnault, F. R.: Vitreous hemorrhage: III. Experimental degeneration of the rabbit retina induced by hemoglobin injection into the vitreous. Arch. Ophthal.83, 470 (1970)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Peep Algvere
    • 1
  • Erik Kock
    • 1
  1. 1.Department of OphthalmologyKarolinska HospitalStockholmSweden

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