Abstract
The bone metabolism in high mountaineering was investigated. The bone densities of 24 members of Himalayan expedition parties were measured before and after expedition by single photon absorptiometry and digital image processing method. As a result, decrease of bone density of 1/6 radial distal portion was 3.2±5.4% (p<0.01). The bone atrophy tended to recover in 5 months and 12 months follow-up measurement, but did not recover completely in a year. Among the indices of bone metabolism, moreover, serum Ca and 1,25-(OH)2D3 decreased of 4.5±4.1% and 22.4±21.9% respectively, during the Himalayan expedition. Concerning the nutritional state, 4.5±4.0% decrease of body weight was observed, but the serum cholesterol was increased of 12.6±14.8%, and this fact could not be explained by malnutrition alone. The special environment of high mountain, that is, low barometric pressure and low oxygen tension, is probably responsible for the bone atrophy.
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Singh, I., Khanna, P. K., Srivastava, M. C., Lal, M., Roy, S. B., and Subramanyam, C. S. V.: Acute mountain sickness. New Engl. J. Med. 280, 175–184, 1969.
Hackett, P. H., and Rennie, D.: Rales, peripheral edema, retinal hemorrhage and mountain sickness: Am. J. Med. 67, 214–218, 1979.
Tanaka, H., Satoh, T., Koike, T., and Hirotani, K.: Problems related with bone in high altitude. Jpn. J. Mountain. Med. 10, 99–104, 1990.
Hayashi, Y., Yamamoto, K., Fukunaga, M., Ishibashi, T., Takahashi, K., and Nishi, Y.: Assessment of bone mass by image analysis of metacarpal bone roentgenograms: A quantitative digital image processing (DIP) method. Radiation Med. 8, 173–178, 1990.
Kishimoto, H.: Clinical study on bone mineral mass in metabolic bone disorders125 I-photon absorptiometry. J. Jpn. Orthop. Ass. 57, 1699–1715, 1983.
Inoue, T., Kusida, K., Miyamoto, S., Sumi, Y., Orimo, H., and Yamashita, G.: Quantitative assessment of bone density on X-ray picture. J. Jpn. Orthop. Ass. 57, 1923–1936, 1983.
Ernsting, J. and Stewart, W. K.: Oxygen deprivation at reduced barometric pressure. In: A textbook of aviation physiology. (Gillies, J. A. ed.), Pergamon Press, Oxford. pp 252–253, 1965.
Makley, J. T., Heiple, K. G., Chase, S. W., and Herndon, C. H.: The effect of reduced barometric pressure on fracture healing in rats. J. Bone & Joint Surg. 49-A, 903–914, 1967.
Penttinen, R., Rantanen, J., and Kulonen, E.: Fracture healing at reduced atmospheric pressure. Acta. Chir. Scand. 138, 147–151, 1972.
Bassett, C. A. L. and Herrmann, I.: Influence of oxygen concentration and mechanical factors on differentiation of connective tissues in vitro. Nature 190, 460–461, 1961.
Brighton, C. T., Ray, R. D., Soble, L. W., and Kuettner, K. E.: In vitro epiphyseal-plate growth in various oxygen tensions. J. Bone & Joint Surg. 51-A, 1383–1396, 1969.
Brighton, C. T. and Heppenstall, R. B.: Oxygen tension in zone of the epiphyseal plate, the metaphysis and diaphysis. J. Bone & Joint Surg. 53-A, 719–728, 1971.
Brighton, C. T. and Krebs, A. G.: Oxygen tension of healing fractures in the rabbit. J. Bone & Joint Surg. 54-A, 323–332, 1972.
Nordin, B. E. C.: Osteoporosis and calcium deficiency. Proc. Nut. Soc. 19, 129–137, 1960.
Nevison, T. O. Jr., Roberts, J. E., and Lackey, W. W.: Nutrition and fluid balance in high altitude mountaineering. Proc. Symposia on Arctic. Biol. and Med. 5, 343–363, 1964.
Surks, M. I., Chinn, K. S. K., and Matoush, L. O.: Alteration in body composition in man after acute exposure to high altitude. J. Appl. Physiol. 21, 1741–1746, 1966.
Kjeldsen, K. and Damgaard, F.: Influence of prolonged carbon monoxide exposure and altitude hypoxia on serum lipids in man. Scand. J. Clin. Lab. Invest. Suppl. 103, 16–19, 1968.
Sakaguchi, T.: Changes of lipid metabolism during adaptation and acclimatization to high altitude. National Def. Med. J. 24, 33–44, 1977.
Hackett, P. H.: Mountain sickness. prevention, recognition, and treatment. The American Alpine Club, Inc, 1980.
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Tanaka, H., Minowa, K., Satoh, T. et al. Bone atrophy at high altitude. J Bone Miner Metab 10, 31–36 (1992). https://doi.org/10.1007/BF02383459
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DOI: https://doi.org/10.1007/BF02383459