Skip to main content
SpringerLink
Log in

A high incidence ofTrypanosoma congolense strains resistant to homidium bromide in Ethiopia

  • Published:
Tropical Animal Health and Production Aims and scope Submit manuscript

Summary

Field investigations at settlements in Didessa valley and Angar valley in Wollega province, Ethiopia, suggested the presence of drug-resistant strains ofTrypanosoma congolense.

Laboratory experiments using mice confirmed a high incidence of resistance to homidium bromide, a phenanthridinium drug.

Résumé

Des investigations en brousse, dans des établissements de Didessa et d'Angar Vallée, dans la province de Wollega, en Ethiopie, ont suggéré l'existence de souches deTrypanosoma congolense résistantes aux trypanocides.

Les recherches en Laboratoire sur souris ont confirmé leur haut degré de résistance au bromure d'homidium, dérivé de la phenanthridine.

Sumario

Se sospechó la presencia de cepas resistentes deTrypanosoma congolense, a las drogas utilizadas en el campo en investigaciones llevadas a cabo en los caceríos del valle de Didessa y Angar en la provincia de Wollega, Etiopía.

Experimentos con ratones en el laboratorio confirmaron una alta incidencia de la resistencia del tripanosoma al bromuro de homidio y al fenantridinio.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Hawking, F. (1963). Drug-resistance ofTrypanosoma congolense and other trypanosomes to quinapyramine, phenanthridines, Berenil and other compounds in mice.Annals of Tropical Medicine and Parasitology,57, 262–282.

    CAS  PubMed  Google Scholar 

  • Killick-Kendrick, R. (1968). The diagnosis of trypanosomiasis of livestock: a review of current techniques.The Veterinary Bulletin,38, 191–197.

    Google Scholar 

  • Mwambu, P. M. (1967). Cattle trypanosomiasis in the area adjoining the South Busoga fly-belt.International Scientific Committee on Trypanosomiasis Research OAU/STRC publication no. 100, p. 25.

  • Mwambu, P. M., Mayende, P. J. &Masinde, A., (1969).East African Trypanosomiasis Research Organization Report, 1969, pp. 128–130.

    Google Scholar 

  • Van Hoeve, K. &Grainge, E. B. (1965).East African Trypanosomiasis Research Organization Report, 1965, pp. 61–63.

    Google Scholar 

  • Walker, P. J. &Watts, J. M. A. (1970).East African Trypanosomiasis Research Organization Report, 1970, p. 58.

    Google Scholar 

  • Watkins, T. I. &Woolf, G. (1952). Effect of changing the quaternizing group on the Trypanocidal activity of Dimidium Bromide.Nature, London,169, 506.

    CAS  Google Scholar 

  • Whiteside, E. F. (1960). Recent work in Kenya on the control of drug-resistant cattle trypanosomiasis.International Scientific Committee on Trypanosomiasis Research, eighth meeting, CCTA publication no. 62, pp. 141–154.

    Google Scholar 

  • Williamson, J. &Stephen, L. E. (1960). A test for drug-resistant trypanosomes in experimental tsetse fly challenge of cattle.Annals of Tropical Medicine and Parasitology,54, 366–370.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Veterinary Services of the Imperial Ethiopian Government, P.O. Box 5416, Addis Ababa, Ethiopia

    J. M. Scott & R. G. Pegram

Authors
  1. J. M. Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. G. Pegram
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scott, J.M., Pegram, R.G. A high incidence ofTrypanosoma congolense strains resistant to homidium bromide in Ethiopia. Trop Anim Health Prod 6, 215–221 (1974). https://doi.org/10.1007/BF02383280

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02383280

Keywords

Search

Navigation